About: Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders

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About: Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mdpi.com/1422-0067/14/8/15681
Description	The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3´ untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3´ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3´ UTRs may contribute to the development of various disorders in humans. The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3´ untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3´ UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3´ UTRs may contribute to the development of various disorders in humans. (en)
Title	Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders (en)
skos:prefLabel	Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders Impaired pre-mRNA processing and altered architecture of 3´ untranslated regions contribute to the development of human disorders (en)
skos:notation	RIV/00209805:_____/13:#0000419!RIV14-GA0-00209805
http://linked.open...avai/predkladatel	Masarykův onkologický ústav
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101), P(GAP301/11/1678), P(GBP206/12/G151)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Michalová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	79117
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000419
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	3´UTR; trinucleotide repeat expansion; polymorphism; mutation; cancer (en)
http://linked.open.../riv/klicoveSlovo	cancer polymorphism 3´UTR trinucleotide repeat expansion mutation
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[F83D4B0C069B]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Sciences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of novel approaches to bioanalysis and molecular diagnostics Regional Centre for Applied Molecular Oncology (RECAMO) The role of the chaperone system in malignant transformation and response to anti-cancer therapy
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Michalová, Eva
http://linked.open...ain/vavai/riv/wos	000328501300025
issn	1422-0067
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/ijms140815681

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