About: The regulation of p53 synthesis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.linkos.cz/files/klinicka-onkologie/174/4123.pdf
Description	The regulation of p53 expression levels is critical in controlling p53 activity in normal and Damaged cells. This is well illustrated by the E3 ubiquitin ligase MDM2 that targets p53 for proteasomal degradation under normal conditions and is essential for controlling p53 activity during development. MDM2 is over-expressed in human cancers and together with some other E3 ligases that have also been implicated in controlling p53 stability, which emphasises the importance of post-translational regulation of p53 expression. At the level of synthesis, TP53 mRNA levels do not change in response to stresses and it is instead its rate of translation initiation that provides the mechanism of choice for expression control. More recent work has shown that TP53 mRNA plays an important role in mediating the cellular regulation of p53 activity. We will discuss the regulation of p53 synthesis and its implications for controlling p53 activity under normal conditions and during different types of stress response. The regulation of p53 expression levels is critical in controlling p53 activity in normal and Damaged cells. This is well illustrated by the E3 ubiquitin ligase MDM2 that targets p53 for proteasomal degradation under normal conditions and is essential for controlling p53 activity during development. MDM2 is over-expressed in human cancers and together with some other E3 ligases that have also been implicated in controlling p53 stability, which emphasises the importance of post-translational regulation of p53 expression. At the level of synthesis, TP53 mRNA levels do not change in response to stresses and it is instead its rate of translation initiation that provides the mechanism of choice for expression control. More recent work has shown that TP53 mRNA plays an important role in mediating the cellular regulation of p53 activity. We will discuss the regulation of p53 synthesis and its implications for controlling p53 activity under normal conditions and during different types of stress response. (en)
Title	The regulation of p53 synthesis The regulation of p53 synthesis (en)
skos:prefLabel	The regulation of p53 synthesis The regulation of p53 synthesis (en)
skos:notation	RIV/00209805:_____/12:#0000300!RIV13-MSM-00209805
http://linked.open...avai/predkladatel	Masarykův onkologický ústav
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika	supplementum 2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ponnuswamy, Annad
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	164695
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/12:#0000300
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53 synthesis; stress response; IRES; protein biosynthetis; physiological stress; RNA-binding proteins (en)
http://linked.open.../riv/klicoveSlovo	stress response IRES RNA-binding proteins p53 synthesis physiological stress protein biosynthetis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[02DB8A923982]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Ponnuswamy, Annad
issn	0862-495X
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The regulation of p53 synthesis

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