About: MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human tumors, including colorectal cancer (CRC). Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend Vogelstein's model of CRC pathogenesis and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in CRC patients, and support diagnosis of CRC among cancer of unknown primary site. MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Changes in the expression profiles of miRNAs have been observed in a variety of human tumors, including colorectal cancer (CRC). Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend Vogelstein's model of CRC pathogenesis and have shown great potential for miRNAs as a novel class of therapeutic targets. Several investigations have also described the ability of miRNA expression profiles to predict prognosis and response to selected treatments in CRC patients, and support diagnosis of CRC among cancer of unknown primary site. (en)
Title	MicroRNAs in colorectal cancer: translation of molecular biology into clinical application MicroRNAs in colorectal cancer: translation of molecular biology into clinical application (en)
skos:prefLabel	MicroRNAs in colorectal cancer: translation of molecular biology into clinical application MicroRNAs in colorectal cancer: translation of molecular biology into clinical application (en)
skos:notation	RIV/00209805:_____/09:#0000097!RIV10-MZ0-00209805
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9076), P(NS9814), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	14 Nov
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Vyzula, Rostislav Svoboda, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	326208
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/09:#0000097
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Molecular biology, colorectal cancer, gene expression profiling, microRNAs (en)
http://linked.open.../riv/klicoveSlovo	microRNAs colorectal cancer Molecular biology gene expression profiling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B560D8EB0AD2]
http://linked.open...i/riv/nazevZdroje	Molecular cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy Identification and functional studies of microRNAs with predictive and prognostic significance in patients with colorectal cancer
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav
http://linked.open...ain/vavai/riv/wos	000272282200001
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1476-4598
number of pages	13 (xsd:int)
is http://linked.open...avai/riv/vysledek of	MicroRNAs in colorectal cancer: translation of molecular biology into clinical application MicroRNAs in colorectal cancer: translation of molecular biology into clinical application MicroRNAs in colorectal cancer: translation of molecular biology into clinical application MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

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