About: CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin

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About: CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using human skin as a model, we have found a selective induction of p53 phosphorylation at the CK2-site in the basal cells of UV irradiated human skin. Given that p63(alpha)(delta)N is required for p53 activation after DNA damage, we found a high proportion of cells co-express p63α(delta)N and CK2-phosphorylated p53 after UV-irradiation. These data identify a physiological model with which to identify signaling pathways that mediate cross-talk between p63α(delta)N and activating p53 kinase pathways after DNA damage in basal cell populations. Using human skin as a model, we have found a selective induction of p53 phosphorylation at the CK2-site in the basal cells of UV irradiated human skin. Given that p63(alpha)(delta)N is required for p53 activation after DNA damage, we found a high proportion of cells co-express p63α(delta)N and CK2-phosphorylated p53 after UV-irradiation. These data identify a physiological model with which to identify signaling pathways that mediate cross-talk between p63α(delta)N and activating p53 kinase pathways after DNA damage in basal cell populations. (en) S použitím lidské kůže jako modelu jsme prokázali selektivní indukci fosforylace p53 v CK2-místě v bazálních buňkách lidské kůže ozářené UV. Nalezli jsme vysoký podíl buněk s CK2-fosforylovaným p53, které taktéž exprimují p63(alfa)(delta)N, potřebný pro aktivaci v případě poškození DNA. Na základě dat jsme nalezli fyziologický model signálních drah, který spojuje p63(alfa)(delta)N a p53 aktivující kinázy v případě poškození DNA v bazální buněčné populaci. (cs)
Title	CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin (en) Fosforylace p53 prostřednictvím CK2 je indukována v bazálních kmenových buňkách exprimujících (delta)Np63 v lidské kůži ozářené UVB (cs)
skos:prefLabel	CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin (en) Fosforylace p53 prostřednictvím CK2 je indukována v bazálních kmenových buňkách exprimujících (delta)Np63 v lidské kůži ozářené UVB (cs)
skos:notation	RIV/00209805:_____/06:0000019!RIV07-MZ0-00209805
http://linked.open.../vavai/riv/strany	2489; 2494
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/05/0416), P(NR8338)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Vojtěšek, Bořivoj Nenutil, Rudolf
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	468832
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/06:0000019
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cell, p63, differentiation, p53 phosphorylation, ATM, CK2 (en)
http://linked.open.../riv/klicoveSlovo	stem cell p63 p53 phosphorylation ATM differentiation CK2
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9988F4CA2394]
http://linked.open...i/riv/nazevZdroje	Cell cycle
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel therapeutic strategies through sensitising tumour cells to anti-cancer drugs by targeting p53-kinases and p53 homologues Functional analysis of the p53-dependent pathways in breast cancer: Integration of genomic and proteomic approaches using DNA-macroarray and SELDI-TOF mass spectrometry techniques
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Vojtěšek, Bořivoj Nenutil, Rudolf
issn	1538-4101
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin

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