About: HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Her-2/PI3K/Akt kinázová signální dráha může hrát specifickou pro-apoptotickou roli u některých typů buněk díky pozitivní regulaci exprese apoptotických receptorů TRAIL-R1 a TRAIL-R2. Potlačení Her2 signalizace prostřednictvím trastuzumabu (Herceptin) vedlo ke snížené odpovědi buněk BT474 odvozených od karcinomu prsu na navození apoptózy ligandem TRAIL. Tento efekt byl pozorován také při inhibici PI3K/Akt kinázové nikoli MAPK/ERK kinázové dráhy. U buněk BT474 inhibice Her-2/PI3K/Akt kinázové signalizace vedla k redukci exprese receptorů pro TRAIL a některých apoptotických procesů navozených TRAILem jako je aktivace kaspázy-8, štěpení proteinu Bid, pokles mitochondriálního potenciálu a štěpení PARP nikoli však aktivace kaspázy-9. (cs)
  • We show that HER2/PI3K/Akt pathway may play a specific pro-apoptotic role in certain cell type by inducing TRAIL-R1 and -R2 expression and thereby enhancing responsiveness to TRAIL. HER2 downregulation by trastuzumab decreased susceptibility of BT474 breast cancer cells to TRAIL-induced apoptosis. This decrease was also observed after exogenous inhibition of PI3-K/Akt kinase, but not MAPK/ERK kinase. In BT474 cells, inhibition of the HER2/PI3K/Akt pathway resulted in downregulation of the pro-apoptotic receptors TRAIL-R1 and TRAIL-R2. TRAIL-induced caspase-8 activation, Bid processing, drop of DeltaPsi(m), and poly ADP-ribose polymerase (PARP) cleavage but not in caspase-9 activation were inhibited in HER2/PI3K/Akt-suppressed BT474 cells.
  • We show that HER2/PI3K/Akt pathway may play a specific pro-apoptotic role in certain cell type by inducing TRAIL-R1 and -R2 expression and thereby enhancing responsiveness to TRAIL. HER2 downregulation by trastuzumab decreased susceptibility of BT474 breast cancer cells to TRAIL-induced apoptosis. This decrease was also observed after exogenous inhibition of PI3-K/Akt kinase, but not MAPK/ERK kinase. In BT474 cells, inhibition of the HER2/PI3K/Akt pathway resulted in downregulation of the pro-apoptotic receptors TRAIL-R1 and TRAIL-R2. TRAIL-induced caspase-8 activation, Bid processing, drop of DeltaPsi(m), and poly ADP-ribose polymerase (PARP) cleavage but not in caspase-9 activation were inhibited in HER2/PI3K/Akt-suppressed BT474 cells. (en)
Title
  • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway
  • Potlačení Her-2 signalizace trastuzumabem a inhibice PI3K/Akt kinázové dráhy (cs)
  • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway (en)
skos:prefLabel
  • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway
  • Potlačení Her-2 signalizace trastuzumabem a inhibice PI3K/Akt kinázové dráhy (cs)
  • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway (en)
skos:notation
  • RIV/00209805:_____/05:#0000017!RIV06-MZ0-00209805
http://linked.open.../vavai/riv/strany
  • 4149; 4158
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ00020980501)
http://linked.open...iv/cisloPeriodika
  • 19
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 523202
http://linked.open...ai/riv/idVysledku
  • RIV/00209805:_____/05:#0000017
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • TRAIL, Apoptosis, HER2/neu, Trastuzumab, PI3K, Breast cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [DEA924EB38F7]
http://linked.open...i/riv/nazevZdroje
  • FEBS Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 579
http://linked.open...iv/tvurceVysledku
  • Dubská, Lenka
http://linked.open...n/vavai/riv/zamer
issn
  • 0014-5793
number of pages
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 117 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software