About: Alterations in IFN signaling in cancer and their potential clinical impact

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We here report on the deficient inducibility of STAT1 phosphorylation at Ser-727 and Tyr-701 in response to IFN-?Ń/-gamma in stage II and III melanoma patients. The absence of STAT1 activation at Ser-727 occurred in three quarters of patients. Induction of STAT1 phosphorylation at Tyr-701 by IFN-alfa was lacking in 63% and by IFN-gamma in 34% of patients. We here report on the deficient inducibility of STAT1 phosphorylation at Ser-727 and Tyr-701 in response to IFN-?Ń/-gamma in stage II and III melanoma patients. The absence of STAT1 activation at Ser-727 occurred in three quarters of patients. Induction of STAT1 phosphorylation at Tyr-701 by IFN-alfa was lacking in 63% and by IFN-gamma in 34% of patients. (en)
Title	Alterations in IFN signaling in cancer and their potential clinical impact Alterations in IFN signaling in cancer and their potential clinical impact (en)
skos:prefLabel	Alterations in IFN signaling in cancer and their potential clinical impact Alterations in IFN signaling in cancer and their potential clinical impact (en)
skos:notation	RIV/00209805:_____/03:00008210!RIV/2004/GA0/L26004/N
http://linked.open.../vavai/riv/strany	S40
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/0370), Z(MZ00020980501)
http://linked.open...iv/cisloPeriodika	suppl.1
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kovařík, Jan Boudný, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	597828
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/03:00008210
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STAT 1;interferons;malignant melanoma (en)
http://linked.open.../riv/klicoveSlovo	STAT 1 interferons malignant melanoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[B749ACA8230F]
http://linked.open...i/riv/nazevZdroje	International journal of molecular medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of STAT 1 and STAT 3 mediated cytokine signaling in normal and cancer cells
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Boudný, Vladimír Kovařík, Jan
http://linked.open...n/vavai/riv/zamer	Biologické, genetické a epidemiologické aspekty malignit a optimalizace diagnosticko-léčebných postupů
issn	1107-3756
number of pages	1 (xsd:int)

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