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| rdf:type
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| rdfs:seeAlso
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| Description
| - Objective: The genotoxic vesicant sulphur mustard [bis-2-(chloroethyl)sulphide] is a chemical warfare agent which is easily available due to its relatively simple synthesis. Thus, sulphur mustard is a potential agent for mass contamination. In this study, we focused on sulphur mustard toxicity and decontamination in a rat model using commercially available detergent mixtures for dermal decontamination. Methods: Male Wistar rats were percutaneously treated with sulphur mustard and subjected to wet decontamination 2 min postexposure. Commercially produced detergents NeodekontTM, ArgosTM, DermogelTM and FloraFreeTM were tested for their decontamination efficacy against an exposed group and their protective ratios determined. Results and conclusion: The results showed that all tested detergent solutions produced an increase in the median lethal dose [LD50 = 9.83 (5.87-13.63) mg.kgMINUS SIGN 1] in comparison to controls, which led to increased survival of experimental animals. In general, all tested detergents provided modest decontamination efficacy (PR = 2.0-5.7). The highest protective ratio (5.7) was consistently achieved with ArgosTM. Accordingly, ArgosTM should be considered in further investigation of mass casualty decontamination.
- Objective: The genotoxic vesicant sulphur mustard [bis-2-(chloroethyl)sulphide] is a chemical warfare agent which is easily available due to its relatively simple synthesis. Thus, sulphur mustard is a potential agent for mass contamination. In this study, we focused on sulphur mustard toxicity and decontamination in a rat model using commercially available detergent mixtures for dermal decontamination. Methods: Male Wistar rats were percutaneously treated with sulphur mustard and subjected to wet decontamination 2 min postexposure. Commercially produced detergents NeodekontTM, ArgosTM, DermogelTM and FloraFreeTM were tested for their decontamination efficacy against an exposed group and their protective ratios determined. Results and conclusion: The results showed that all tested detergent solutions produced an increase in the median lethal dose [LD50 = 9.83 (5.87-13.63) mg.kgMINUS SIGN 1] in comparison to controls, which led to increased survival of experimental animals. In general, all tested detergents provided modest decontamination efficacy (PR = 2.0-5.7). The highest protective ratio (5.7) was consistently achieved with ArgosTM. Accordingly, ArgosTM should be considered in further investigation of mass casualty decontamination. (en)
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| Title
| - A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard
- A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard (en)
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| skos:prefLabel
| - A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard
- A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard (en)
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| skos:notation
| - RIV/00179906:_____/13:10159526!RIV14-MZ0-00179906
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00179906:_____/13:10159526
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Neodekont; Dermogel; FloraFree; Argos; protective ratio; skin; tenside; Mass decontamination (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Cutaneous and Ocular Toxicology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Jošt, Petr
- Kuča, Kamil
- Misík, Jan
- Pavlíková, Růžena
- Vodáková, Eva
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
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| http://bibframe.org/vocab/doi
| - 10.3109/15569527.2012.730087
|
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