About: In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ingentaconnect.com/content/ben/mc/2012/00000008/00000004/art00028
Description	The development of new antimicrobial agents for the treatment of infectious diseases remains challenging due to the increasing impact of antibiotic resistance. Since salicylanilides and esters of pyrazine-2-carboxylic acid have been described as potential antimicrobials, we have designed and synthesized a series of 2-(phenylcarbamoyl) phenyl pyrazine-2-carboxylates. These were evaluated in vitro for the activity against fungi and Gram-positive and Gram-negative bacteria. All derivatives showed significant antibacterial activity against Gram-positive strains (MIC }= 0.98 mu mol/L) including methicillin-resistant Staphylococcus aureus. The most active molecule was 5-chloro-2-(3-chlorophenylcarbamoyl) phenyl pyrazine-2-carboxylate. With one exception these esters were at least partly active against fungi tested strains, in particular against mould strains (MIC }= 1.95 mu mol/L). The most active antifungal agent overall proved to be 2-(4-bromophenylcarbamoyl)-4-chlorophenyl pyrazine-2-carboxylate. The development of new antimicrobial agents for the treatment of infectious diseases remains challenging due to the increasing impact of antibiotic resistance. Since salicylanilides and esters of pyrazine-2-carboxylic acid have been described as potential antimicrobials, we have designed and synthesized a series of 2-(phenylcarbamoyl) phenyl pyrazine-2-carboxylates. These were evaluated in vitro for the activity against fungi and Gram-positive and Gram-negative bacteria. All derivatives showed significant antibacterial activity against Gram-positive strains (MIC }= 0.98 mu mol/L) including methicillin-resistant Staphylococcus aureus. The most active molecule was 5-chloro-2-(3-chlorophenylcarbamoyl) phenyl pyrazine-2-carboxylate. With one exception these esters were at least partly active against fungi tested strains, in particular against mould strains (MIC }= 1.95 mu mol/L). The most active antifungal agent overall proved to be 2-(4-bromophenylcarbamoyl)-4-chlorophenyl pyrazine-2-carboxylate. (en)
Title	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates (en)
skos:prefLabel	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates (en)
skos:notation	RIV/00179906:_____/12:10128912!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(NS10367), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Buchta, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	141034
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10128912
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	salicylanilide ester; salicylanilide; pyrazine-2-carboxylic acid este; in vitro activit; antifungal activity; Antibacterial activity (en)
http://linked.open.../riv/klicoveSlovo	antifungal activity salicylanilide salicylanilide ester Antibacterial activity in vitro activit pyrazine-2-carboxylic acid este
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C639222AE47A]
http://linked.open...i/riv/nazevZdroje	Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Buchta, Vladimír Krátký, Martin Vinšová, Jarmila
http://linked.open...ain/vavai/riv/wos	000309524600028
issn	1573-4064
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/157340612801216346
is http://linked.open...avai/riv/vysledek of	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates

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