About: In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.tswj.com/2012/290628/
Description	The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl) phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations }= 0.98 mu mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl) phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl) phenyl benzoate. The antifungal activity is significantly lower. The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl) phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations }= 0.98 mu mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl) phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl) phenyl benzoate. The antifungal activity is significantly lower. (en)
Title	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates (en)
skos:prefLabel	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates (en)
skos:notation	RIV/00179906:_____/12:10124293!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(NS10367), S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	2012
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Buchta, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	141033
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10124293
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antifungal activity, salicylanilide benzoate; antibacterial activity (en)
http://linked.open.../riv/klicoveSlovo	antibacterial activity antifungal activity salicylanilide benzoate
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[19487443163E]
http://linked.open...i/riv/nazevZdroje	The Scientific World Journal
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Buchta, Vladimír Krátký, Martin Vinšová, Jarmila
http://linked.open...ain/vavai/riv/wos	000304801900001
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	1537-744X
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1100/2012/290628
is http://linked.open...avai/riv/vysledek of	In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

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