About: Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity     Goto   Sponge   NotDistinct   Permalink

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  • The effect of dexrazoxane (DEX) on the catecholamine model of acute myocardial infarction was analyzed. DEX partly decreased the mortality, reduced myocardial calcium overload, histological impairment, and peripheral haemodynamic disturbances 24 h after isoprenaline administration. Its protective effects are probably mediated by inhibition of late myocardial impairment and ventricular fibrillation likely due to inhibition of myocardial calcium overload. Complementary in vitro experiments suggested that iron chelation properties of DEX apparently did not play the major role.
  • The effect of dexrazoxane (DEX) on the catecholamine model of acute myocardial infarction was analyzed. DEX partly decreased the mortality, reduced myocardial calcium overload, histological impairment, and peripheral haemodynamic disturbances 24 h after isoprenaline administration. Its protective effects are probably mediated by inhibition of late myocardial impairment and ventricular fibrillation likely due to inhibition of myocardial calcium overload. Complementary in vitro experiments suggested that iron chelation properties of DEX apparently did not play the major role. (en)
Title
  • Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity
  • Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity (en)
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  • Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity
  • Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity (en)
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  • RIV/00179906:_____/12:10124288!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel
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  • I, S
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  • 4
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  • 130896
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  • RIV/00179906:_____/12:10124288
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  • myocardium; isoprenaline; cardiotoxicity; acute myocardial infarction; iron; catecholamine; dexrazoxane (en)
http://linked.open.../riv/klicoveSlovo
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  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [65D1EA7102B5]
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  • Canadian Journal of Physiology and Pharmacology
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  • 90
http://linked.open...iv/tvurceVysledku
  • Palička, Vladimír
  • Macáková, Kateřina
  • Filipský, Tomáš
  • Hrdina, Radomír
  • Mladěnka, Přemysl
  • Vávrová, Jaroslava
  • Zatloukalová, Libuše
  • Holečková, Magdalena
  • Semecký, Vladimír
http://linked.open...ain/vavai/riv/wos
  • 000302241200012
issn
  • 0008-4212
number of pages
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  • 10.1139/Y2012-009
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