About: A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:seeAlso
Description
  • The study describes a model of early sepsis induced in Wistar rats by a bolus injection of bacterial lipopolysaccharide (LPS) combined with interleukin-2 (IL-2). Both the separate and combined effects of LPS+IL-2 and gentamicin (GE) on glomerular filtration rate (GFR), tubular function and plasma biochemical parameters were evaluated. The major characteristics of the model are as follows: systemic microvascular leakage, a drop in GFR with only partially preserved tubular compensatory mechanisms, unchanged renal morphology, histologically proven pulmonary injuries and splenic alterations - signs of activation. In the range of therapeutic steady-state concentrations maintained over 3 hours, GE does not reduce GFR either in nonseptic or LPS+IL-2-treated rats. This is in contrast to its marked decrease due to the effect of LPS+IL-2 alone. An enlarged distribution volume and half-life along with a drop in renal clearance of GE proportional to that of GFR are the remarkable changes of GE disposition in this model. Nonrenal routes which, for the most part, compensate the reduced renal CL of GE in septic animals deserve further study.
  • The study describes a model of early sepsis induced in Wistar rats by a bolus injection of bacterial lipopolysaccharide (LPS) combined with interleukin-2 (IL-2). Both the separate and combined effects of LPS+IL-2 and gentamicin (GE) on glomerular filtration rate (GFR), tubular function and plasma biochemical parameters were evaluated. The major characteristics of the model are as follows: systemic microvascular leakage, a drop in GFR with only partially preserved tubular compensatory mechanisms, unchanged renal morphology, histologically proven pulmonary injuries and splenic alterations - signs of activation. In the range of therapeutic steady-state concentrations maintained over 3 hours, GE does not reduce GFR either in nonseptic or LPS+IL-2-treated rats. This is in contrast to its marked decrease due to the effect of LPS+IL-2 alone. An enlarged distribution volume and half-life along with a drop in renal clearance of GE proportional to that of GFR are the remarkable changes of GE disposition in this model. Nonrenal routes which, for the most part, compensate the reduced renal CL of GE in septic animals deserve further study. (en)
Title
  • A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2
  • A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2 (en)
skos:prefLabel
  • A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2
  • A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2 (en)
skos:notation
  • RIV/00179906:_____/12:10123852!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S
http://linked.open...iv/cisloPeriodika
  • 10
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 120546
http://linked.open...ai/riv/idVysledku
  • RIV/00179906:_____/12:10123852
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • multi-organ injury; early endotoxemia; LPSIL-2; pharmacokinetics; sepsis; gentamicin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [58EE21FE6F85]
http://linked.open...i/riv/nazevZdroje
  • Biological and Pharmaceutical Bulletin
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 35
http://linked.open...iv/tvurceVysledku
  • Chládek, Jaroslav
  • Springer, Drahomíra
  • Šenkeřík, Marian
  • Martínková, Jiřina
  • Krs, Otakar
  • Slížová, Dáša
  • Studená, Šárka
http://linked.open...ain/vavai/riv/wos
  • 000309332600015
issn
  • 0918-6158
number of pages
http://bibframe.org/vocab/doi
  • 10.1248/bpb.b12-00205
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 41 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software