About: Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats

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About: Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0014299912005468
Description	The present paper describes our investigation of the effect of epigallocatechin-gallate (EGCG), the major active ingredient from the green tea, on liver cholesterol metabolism in control and ethinylestradiol-treated rats. The results demonstrated that EGCG administration to control rats did not change plasma total cholesterol, but reduced VLDL cholesterol. However, EGCG markedly enhanced biliary cholesterol and phospholipid secretion, despite the decrease in bile flow and biliary bile acid secretion. In ethinylestradiol treated rats, EGCG caused reduction in hepatic cholesterol accumulation and consequently also mitigation of drug-induced hepatomegaly. These effect of EGCG were attributable to its inducing effect on protein expression of ATP-binding cassette transporter G5 and 8 (ABCG5/8) - i.e. cholesterol biliary exporter, and the reduced expression of acyl-CoA:cholesterol acyltransferase (ACAT2) protein - i.e. limiting step for cholesterol liver storage and VLDL production. Our data for the first time demonstrated these metabolic effect for such a commonly used substance. The present paper describes our investigation of the effect of epigallocatechin-gallate (EGCG), the major active ingredient from the green tea, on liver cholesterol metabolism in control and ethinylestradiol-treated rats. The results demonstrated that EGCG administration to control rats did not change plasma total cholesterol, but reduced VLDL cholesterol. However, EGCG markedly enhanced biliary cholesterol and phospholipid secretion, despite the decrease in bile flow and biliary bile acid secretion. In ethinylestradiol treated rats, EGCG caused reduction in hepatic cholesterol accumulation and consequently also mitigation of drug-induced hepatomegaly. These effect of EGCG were attributable to its inducing effect on protein expression of ATP-binding cassette transporter G5 and 8 (ABCG5/8) - i.e. cholesterol biliary exporter, and the reduced expression of acyl-CoA:cholesterol acyltransferase (ACAT2) protein - i.e. limiting step for cholesterol liver storage and VLDL production. Our data for the first time demonstrated these metabolic effect for such a commonly used substance. (en)
Title	Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats (en)
skos:prefLabel	Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats (en)
skos:notation	RIV/00179906:_____/12:10123846!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hyšpler, Radomír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	134602
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10123846
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ethinylestradiol; epigallocatechin gallate; biliary secretion; cholesterol metabolism (en)
http://linked.open.../riv/klicoveSlovo	ethinylestradiol biliary secretion cholesterol metabolism epigallocatechin gallate
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[711B76D7B33E]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	691
http://linked.open...iv/tvurceVysledku	Hyšpler, Radomír Mičuda, Stanislav Kolouchová, Gabriela Cermanová, Jolana Hiršová, Petra Doleželová, Eva Kadová, Zuzana
http://linked.open...ain/vavai/riv/wos	000307815800005
issn	0014-2999
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejphar.2012.06.034
is http://linked.open...avai/riv/vysledek of	Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats

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