About: CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to Ig superfamily, containing two immunoglobulin-like domain (V, C). CD200 is broadly distributed on a variety of cell types, whereas CD200R is primarily expressed on myeloid and lymphoid cells. They fulfill multiple functions in tuning of inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cells inhibition. It was confirmed that the CD200R activation stimulates differentiation of T cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from Th1 to Th2 pattern, potentiate an antiinflammatory IL-10 and TGF-β synthesis. CD200/CD200R are required for maintaining self-tolerance. Many studies demonstrated the importance of CD200 in controlling autoimmunity, inflammation, development and spread of cancer, hypersensitivity, and spontaneous fetal loss. CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to Ig superfamily, containing two immunoglobulin-like domain (V, C). CD200 is broadly distributed on a variety of cell types, whereas CD200R is primarily expressed on myeloid and lymphoid cells. They fulfill multiple functions in tuning of inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cells inhibition. It was confirmed that the CD200R activation stimulates differentiation of T cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from Th1 to Th2 pattern, potentiate an antiinflammatory IL-10 and TGF-β synthesis. CD200/CD200R are required for maintaining self-tolerance. Many studies demonstrated the importance of CD200 in controlling autoimmunity, inflammation, development and spread of cancer, hypersensitivity, and spontaneous fetal loss. (en)
Title	CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function (en)
skos:prefLabel	CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function (en)
skos:notation	RIV/00179906:_____/12:10123623!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Krejsek, Jan Andrýs, Ctirad Kuneš, Pavel Kondělková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	126165
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10123623
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IDO; inflammation; inhibition mechanisms; CD200R; CD200 (en)
http://linked.open.../riv/klicoveSlovo	CD200 CD200R IDO inhibition mechanisms inflammation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8C091BD23A5C]
http://linked.open...i/riv/nazevZdroje	Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Andrýs, Ctirad Krejsek, Jan Koláčková, Martina Kuneš, Pavel Holmannová, Drahomíra Kondělková, Kateřina
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby
issn	1211-4286
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	CD200-CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; part I: CD200/CD200R structure, activation, and function

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software