About: Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment

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About: Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). Methods: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67+-9 years) on ASA therapy in 10 +- 6 months interval. STR was assessed in 15 patients (6 females, mean age 61 +- 7 years) with 10 measurements on 2 consecutive days. Results: There was no correlation between both measurements in the long-term part of the study and also Bland Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of 0.800 (p{0.05), confirmed by Bland Altman plot. Conclusions: Whereas short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted. Background: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). Methods: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67+-9 years) on ASA therapy in 10 +- 6 months interval. STR was assessed in 15 patients (6 females, mean age 61 +- 7 years) with 10 measurements on 2 consecutive days. Results: There was no correlation between both measurements in the long-term part of the study and also Bland Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of 0.800 (p{0.05), confirmed by Bland Altman plot. Conclusions: Whereas short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted. (en)
Title	Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment (en)
skos:prefLabel	Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment (en)
skos:notation	RIV/00179906:_____/12:10108265!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9174)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bis, Josef Vojáček, Jan Malý, Jaroslav Pecka, Miroslav Ševčík, Róbert Ševčíková, Hana Fátorová, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	138294
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/12:10108265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	reproducibility; light transmission aggregometry; acetylsalicylic acid; platelets (en)
http://linked.open.../riv/klicoveSlovo	light transmission aggregometry acetylsalicylic acid platelets reproducibility
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[852DB34C7BD7]
http://linked.open...i/riv/nazevZdroje	Clinical and Applied Thrombosis/Hemostasis
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination and significance of resistance to antiplatelet therapy
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Malý, Jaroslav Pecka, Miroslav Vojáček, Jan Bis, Josef Ševčík, Róbert Ševčíková, Hana Fátorová, Ilona
http://linked.open...ain/vavai/riv/wos	000301287300008
issn	1076-0296
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1076029611418961
is http://linked.open...avai/riv/vysledek of	Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment

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