About: Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2613.2011.00765.x/pdf
Description	There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to compare acute toxic effect of a model hepatotoxin thioacetamide (100 mg/ kg) on intact rat liver and rat liver affected by high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Serum biochemical parameters (ALT, AST, ALP, and bilirubin) and TNFalpha, hepatic IL-6 and TGFbeta1 and centrilobular necrosis with subsequent regenerative response of the liver were significantly higher in high-fat diet fed rats after thioacetamide administration. Steatotic rat liver, compared to non-steatotic liver, is more sensitive to acute toxic effect of thioacetamide. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to compare acute toxic effect of a model hepatotoxin thioacetamide (100 mg/ kg) on intact rat liver and rat liver affected by high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). Serum biochemical parameters (ALT, AST, ALP, and bilirubin) and TNFalpha, hepatic IL-6 and TGFbeta1 and centrilobular necrosis with subsequent regenerative response of the liver were significantly higher in high-fat diet fed rats after thioacetamide administration. Steatotic rat liver, compared to non-steatotic liver, is more sensitive to acute toxic effect of thioacetamide. (en)
Title	Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? (en)
skos:prefLabel	Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? (en)
skos:notation	RIV/00179906:_____/11:10105385!RIV12-MZ0-00179906
http://linked.open...avai/predkladatel	Fakultní nemocnice Hradec Králové
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GP305/08/P184), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Podhola, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	205870
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/11:10105385
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Thioacetamide; Oxidative stress; Hepatotoxicity; Fatty liver; Cytokines (en)
http://linked.open.../riv/klicoveSlovo	Fatty liver Thioacetamide Oxidative stress Hepatotoxicity Cytokines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[43BAE10ECDC1]
http://linked.open...i/riv/nazevZdroje	International Journal of Experimental Pathology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Is the liver affected by non-alcoholic liver disease (NAFLD) more sensitive to toxic injury?
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Podhola, Miroslav Roušar, Tomáš Kučera, Otto Lotková, Halka Staňková, Pavla Červinková, Zuzana Mezera, Vojtěch
http://linked.open...ain/vavai/riv/wos	000292331700008
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0959-9673
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-2613.2011.00765.x
is http://linked.open...avai/riv/vysledek of	Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?

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