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  • During the last two decades, the treatment of OPP exposure has become more widely discussed because of growing agricultural production, industrialisation and harmful social issues (e.g. suicides). In this review is summarised the design, evaluation and structure-activity relationship studies of recently produced AChE reactivators. Since pralidoxime, over 300 oximes have been produced or tested against OPP poisoning, and several novel compounds show very promising abilities as comparable (or higher) to commercial oximes. Some of these are highlighted for their further testing of OPP exposure, and additionally, the main structure-activity relationship of AChE reactivators against OPP are discussed.
  • During the last two decades, the treatment of OPP exposure has become more widely discussed because of growing agricultural production, industrialisation and harmful social issues (e.g. suicides). In this review is summarised the design, evaluation and structure-activity relationship studies of recently produced AChE reactivators. Since pralidoxime, over 300 oximes have been produced or tested against OPP poisoning, and several novel compounds show very promising abilities as comparable (or higher) to commercial oximes. Some of these are highlighted for their further testing of OPP exposure, and additionally, the main structure-activity relationship of AChE reactivators against OPP are discussed. (en)
Title
  • Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
  • Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides (en)
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  • Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
  • Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides (en)
skos:notation
  • RIV/00179906:_____/11:10099227!RIV13-MZ0-00179906
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • I, P(ME09086)
http://linked.open...iv/cisloPeriodika
  • 4
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http://linked.open...aciTvurceVysledku
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  • 193530
http://linked.open...ai/riv/idVysledku
  • RIV/00179906:_____/11:10099227
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • SAR; oxime; reactivation; insecticide; pesticide; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [FBE1A09EAE2F]
http://linked.open...i/riv/nazevZdroje
  • Medicinal Research Reviews
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  • 31
http://linked.open...iv/tvurceVysledku
  • Doležal, Martin
  • Kuča, Kamil
  • Musílek, Kamil
  • Gunn-Moore, Frank
http://linked.open...ain/vavai/riv/wos
  • 000292570100003
issn
  • 0198-6325
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/med.20192
is http://linked.open...avai/riv/vysledek of
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