About: Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Elevated expression of angiopoietin-2 (Ang-2), was recently reported in CLL. We quantitated Ang-2 mRNA in purified mononuclear cells of 33 untreated CLL patients and compared the transcript levels to traditional as well as modern prognostic factors in patients with CLL. Elevated Ang-2 mRNA concentrations were detected in 12 cases; 21 patients had very low or undetectable levels of Ang-2 transcript. There was significant association between high Ang-2 mRNA levels and unmutated IgVH genes (n=27, P=0.010) and with CD38 expression (n=32, P=0.011), but not with ZAP-70 expression (n=32,P=0.784), Rai stage (n=33, P=0.305) or stable versus progressive clinical course (n=33,P=0.443). There was a trend towards shorter progression-free survival in patients with high Ang-2 expression; however, it did not reach statistical significance (P=0.090). Our pilot data show that Ang-2 mRNA is differentially expressed in patients with CLL and its increased expression appears to be associated with poor prognostic features. Elevated expression of angiopoietin-2 (Ang-2), was recently reported in CLL. We quantitated Ang-2 mRNA in purified mononuclear cells of 33 untreated CLL patients and compared the transcript levels to traditional as well as modern prognostic factors in patients with CLL. Elevated Ang-2 mRNA concentrations were detected in 12 cases; 21 patients had very low or undetectable levels of Ang-2 transcript. There was significant association between high Ang-2 mRNA levels and unmutated IgVH genes (n=27, P=0.010) and with CD38 expression (n=32, P=0.011), but not with ZAP-70 expression (n=32,P=0.784), Rai stage (n=33, P=0.305) or stable versus progressive clinical course (n=33,P=0.443). There was a trend towards shorter progression-free survival in patients with high Ang-2 expression; however, it did not reach statistical significance (P=0.090). Our pilot data show that Ang-2 mRNA is differentially expressed in patients with CLL and its increased expression appears to be associated with poor prognostic features. (en)
Title	Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features (en)
skos:prefLabel	Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features (en)
skos:notation	RIV/00179906:_____/10:10062300!RIV11-MZ0-00179906
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620820), Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Krejsek, Jan Malý, Jaroslav Pecka, Miroslav Smolej, Lukáš Motyčková, Monika Vroblová, Vladimíra Vrbacký, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Hradec Králové
http://linked.open...dnocenehoVysledku	246939
http://linked.open...ai/riv/idVysledku	RIV/00179906:_____/10:10062300
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prognosis; CLL; chronic lymphocytic leukemia; angiopoietin-2; angiopoiesis (en)
http://linked.open.../riv/klicoveSlovo	angiopoiesis angiopoietin-2 chronic lymphocytic leukemia CLL prognosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F0B59D4598DA]
http://linked.open...i/riv/nazevZdroje	Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Krejsek, Jan Malý, Jaroslav Peková, Soňa Pecka, Miroslav Červinka, Miroslav Smolej, Lukáš Vroblová, Vladimíra Vrbacký, Filip Hrudková, Monika
http://linked.open...ain/vavai/riv/wos	000280648600004
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement Nové diagnostické indikátory a léčebné postupy v závislosti na různých obdobích života s důrazem na stáří
issn	1024-5332
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features

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