About: Urinary mutagenicity and genotoxic risk in children with psoriasis after therapeutic exposure to polycyclic aromatic hydrocarbons and ultraviolet radiation     Goto   Sponge   NotDistinct   Permalink

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  • We evaluated dermal absorption of polycyclic aromatic hydrocarbons (PAHs) as well as the mutagenic and genotoxic effects of GR in 16 children with psoriasis, by determining levels of 1-hydroxypyrene (1-OHP), 1-,2-,3-,4-hydroxyphenanthrene, (1-OHPhe, 2-OHPhe, 3-OHPhe, and 4-OHPhe), urinary mutagenicity (Salmonella mutagenicity assay, Ames test) and numbers of chromosomal aberrations in peripheral lymphocytes (CA), in urine and/or blood, before and after GR. In conclusion, our results demonstrate mutagenic and temporary genotoxic effects of GR in the group of 16 treated child patients.
  • We evaluated dermal absorption of polycyclic aromatic hydrocarbons (PAHs) as well as the mutagenic and genotoxic effects of GR in 16 children with psoriasis, by determining levels of 1-hydroxypyrene (1-OHP), 1-,2-,3-,4-hydroxyphenanthrene, (1-OHPhe, 2-OHPhe, 3-OHPhe, and 4-OHPhe), urinary mutagenicity (Salmonella mutagenicity assay, Ames test) and numbers of chromosomal aberrations in peripheral lymphocytes (CA), in urine and/or blood, before and after GR. In conclusion, our results demonstrate mutagenic and temporary genotoxic effects of GR in the group of 16 treated child patients. (en)
Title
  • Urinary mutagenicity and genotoxic risk in children with psoriasis after therapeutic exposure to polycyclic aromatic hydrocarbons and ultraviolet radiation
  • Urinary mutagenicity and genotoxic risk in children with psoriasis after therapeutic exposure to polycyclic aromatic hydrocarbons and ultraviolet radiation (en)
skos:prefLabel
  • Urinary mutagenicity and genotoxic risk in children with psoriasis after therapeutic exposure to polycyclic aromatic hydrocarbons and ultraviolet radiation
  • Urinary mutagenicity and genotoxic risk in children with psoriasis after therapeutic exposure to polycyclic aromatic hydrocarbons and ultraviolet radiation (en)
skos:notation
  • RIV/00179906:_____/10:10057492!RIV11-MZ0-00179906
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 294552
http://linked.open...ai/riv/idVysledku
  • RIV/00179906:_____/10:10057492
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ultraviolet radiation; polycyclic aromatic hydrocarbons; therapeutic exposure; psoriasis; children; genotoxic risk; mutagenicity test; Chromosomal aberations (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [3463C29E3CBF]
http://linked.open...i/riv/nazevZdroje
  • Mutation Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 696
http://linked.open...iv/tvurceVysledku
  • Kremláček, Jan
  • Černá, Milena
  • Šmejkalová, Jindra
  • Fiala, Zdeněk
  • Borská, Lenka
  • Kučera, Ivan
  • Hamáková, Květoslava
  • Pelikánová, Denisa
http://linked.open...ain/vavai/riv/wos
  • 000276212500009
http://linked.open...n/vavai/riv/zamer
issn
  • 0027-5107
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