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  • We evaluated dermal absorption of polycyclic aromatic hydrocarbons (PAH) as well as the genotoxic and apoptotic effects of Goeckerman therapy (GT) in 20 patients with psoriasis, by determining numbers of chromosomal abnormalities in peripheral lymphocytes, and levels of 1-hydroxypyrene (1-OHP), p53 protein and soluble FasL (sFasL) in urine and/or blood, before and after GT. Psoriasis Area and Severity Index (PASI) score was used to evaluate clinical efficacy of GT. Our results demonstrate high dermal absorption of PAH during GT and provide evidence that GT promotes genotoxicity and apoptosis.
  • We evaluated dermal absorption of polycyclic aromatic hydrocarbons (PAH) as well as the genotoxic and apoptotic effects of Goeckerman therapy (GT) in 20 patients with psoriasis, by determining numbers of chromosomal abnormalities in peripheral lymphocytes, and levels of 1-hydroxypyrene (1-OHP), p53 protein and soluble FasL (sFasL) in urine and/or blood, before and after GT. Psoriasis Area and Severity Index (PASI) score was used to evaluate clinical efficacy of GT. Our results demonstrate high dermal absorption of PAH during GT and provide evidence that GT promotes genotoxicity and apoptosis. (en)
Title
  • Genotoxic and apoptotic effects of Goeckerman therapy for psoriasis
  • Genotoxic and apoptotic effects of Goeckerman therapy for psoriasis (en)
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  • Genotoxic and apoptotic effects of Goeckerman therapy for psoriasis
  • Genotoxic and apoptotic effects of Goeckerman therapy for psoriasis (en)
skos:notation
  • RIV/00179906:_____/10:10057487!RIV11-MZ0-00179906
http://linked.open...avai/riv/aktivita
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  • S, Z(MZ0FNHK2005)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
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  • 260483
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  • RIV/00179906:_____/10:10057487
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  • psoriasis; Goeckerman therapy; apoptotic effects; Genotoxic (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [1EAF95EC8E01]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Dermatology
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  • 49
http://linked.open...iv/tvurceVysledku
  • Andrýs, Ctirad
  • Krejsek, Jan
  • Kremláček, Jan
  • Palička, Vladimír
  • Fiala, Zdeněk
  • Borská, Lenka
  • Hamáková, Květoslava
  • Ranná, Diana
http://linked.open...ain/vavai/riv/wos
  • 000274716100009
http://linked.open...n/vavai/riv/zamer
issn
  • 0011-9059
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