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| rdfs:seeAlso
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| Description
| - pontaneous hepatic bleeding is a rare but potentially life-threatening complica - tion of primary systemic amyloidosis . Although the liver is a common site of amyloid deposi - tion, clinical presentation is usually mild or absent . Case: We report a case of a female patient, who had been repeatedly surgically revised because of liver rupture and hemoperitoneum . Initially, the computed tomography finding was interpreted as liver hemangioma . However, based on liver biopsy, the diagnosis had to be changed to primary systemic amyloidosis, and the patient was referred to our hematooncology department . Due to a considerably ad - vanced disease, the patient was eligible only for palliative chemotherapy with cyclophospha - mide and dexamethasone, which could not deflect the course of rapidly progressing liver de - struction . Conclusion: The cause behind ruptured and bleeding liver does not always need to be hemangioma but rather amyloidosis . In cases of advanced disease and in patients with contraindications for aggressive treatment, the outlook for complete hematological and organ treatment response is very limited . An early diagnosis is of utmost importance . Although liver biopsy brings the definite results, screening for monoclonal protein in serum or urine, leading to a search for AL amyloidosis, may be sufficient for diagnosis . The presence of some of the warning signs (B-symptoms such as fevers or subfebrile temperatures, fatigue, weight loss; and paraneoplastic laboratory findings such as elevated C-reactive protein and erythrocyte sedimentation rate) should raise suspicion of a lymphoproliferative disease
- pontaneous hepatic bleeding is a rare but potentially life-threatening complica - tion of primary systemic amyloidosis . Although the liver is a common site of amyloid deposi - tion, clinical presentation is usually mild or absent . Case: We report a case of a female patient, who had been repeatedly surgically revised because of liver rupture and hemoperitoneum . Initially, the computed tomography finding was interpreted as liver hemangioma . However, based on liver biopsy, the diagnosis had to be changed to primary systemic amyloidosis, and the patient was referred to our hematooncology department . Due to a considerably ad - vanced disease, the patient was eligible only for palliative chemotherapy with cyclophospha - mide and dexamethasone, which could not deflect the course of rapidly progressing liver de - struction . Conclusion: The cause behind ruptured and bleeding liver does not always need to be hemangioma but rather amyloidosis . In cases of advanced disease and in patients with contraindications for aggressive treatment, the outlook for complete hematological and organ treatment response is very limited . An early diagnosis is of utmost importance . Although liver biopsy brings the definite results, screening for monoclonal protein in serum or urine, leading to a search for AL amyloidosis, may be sufficient for diagnosis . The presence of some of the warning signs (B-symptoms such as fevers or subfebrile temperatures, fatigue, weight loss; and paraneoplastic laboratory findings such as elevated C-reactive protein and erythrocyte sedimentation rate) should raise suspicion of a lymphoproliferative disease (en)
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| Title
| - Extensive Al amyloidosis presenting with recurrent liver hemorrhage and hemoperitoneum: case report and literature review
- Extensive Al amyloidosis presenting with recurrent liver hemorrhage and hemoperitoneum: case report and literature review (en)
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| skos:prefLabel
| - Extensive Al amyloidosis presenting with recurrent liver hemorrhage and hemoperitoneum: case report and literature review
- Extensive Al amyloidosis presenting with recurrent liver hemorrhage and hemoperitoneum: case report and literature review (en)
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| skos:notation
| - RIV/00159816:_____/13:00060774!RIV14-MZ0-00159816
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00159816:_____/13:00060774
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - B-symptoms; computed tomography; hemangiosarcoma; hemoperitoneum; amyloidosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Mayer, J.
- Adam, Z.
- Vaníček, Jiří
- Szturz, P.
- Navrátil, M.
- Kyclová, J.
- Moulis, M.
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| issn
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| number of pages
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