About: Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells

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About: Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug resistance of tumor cells can be significantly modified by specific features of tumor microenvironnnent, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. Methods:The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram, DSF)/ Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. Results: We show that acidic pH significantly potentiates toxicity of DSF/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFKB activity and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironnnent enhances cytotoxicity of DSF/Cu2+ to breast and colon cancer cells. Background: Resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug resistance of tumor cells can be significantly modified by specific features of tumor microenvironnnent, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. Methods:The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram, DSF)/ Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. Results: We show that acidic pH significantly potentiates toxicity of DSF/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFKB activity and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironnnent enhances cytotoxicity of DSF/Cu2+ to breast and colon cancer cells. (en)
Title	Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells (en)
skos:prefLabel	Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells (en)
skos:notation	RIV/00159816:_____/13:00060539!RIV14-MZ0-00159816
http://linked.open...avai/predkladatel	Fakultní nemocnice u sv. Anny v Brně
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(NT13441)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Beneš, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice u sv.Anny v Brně
http://linked.open...dnocenehoVysledku	59342
http://linked.open...ai/riv/idVysledku	RIV/00159816:_____/13:00060539
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tumor microenvironment; Disulfiram Reactive oxygen species; Cytotoxicity; Colon cancer; Breast cancer (en)
http://linked.open.../riv/klicoveSlovo	Disulfiram Reactive oxygen species Tumor microenvironment Breast cancer Cytotoxicity Colon cancer
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[7BA598397887]
http://linked.open...i/riv/nazevZdroje	Chemotherapy
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Beneš, Petr Smarda, Jan Hankeova, Tereza Navrátilová, Jarmila
http://linked.open...ain/vavai/riv/wos	000325833000006
issn	0009-3157
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000353915

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