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| Description
| - Introduction: Recent research suggests that the multiplicity in recurrent pleomorphic adenoma (PA) might result from migration of its cells through lymphatics. This process in malignancies is mediated by vascular endothelial factors C and D (VEGF-C/D). Authors present very first study investigating immunohistoexpression of VEGF-C/D and lymphatic vessel density (LVD) in PA. Materials&Methods: Six non-recurrent, 4 primary-to-recur and 10 recurrent PAs were stained. The histoscore was calculated as a sum of staining intensity (0=absent to 3=strong) and the percentage of positive tumor cells (scored as 0 (0-19 %), 1 (20-39%), 2 (40-50%) and 3 (60-100%)). Intra- and peritumoral LVD was assessed using D2-40 antibody. Results: All but one sample were VEGF-C negative. The differences in VEGF-D histoscore among non-recurrent, primary-to-recur, and recurrent PAs were not significant (p>0.05). The VEGF-D histoscore didn’t correlate with peritumoral LVD (p>0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p=0.01). Conclusion: Practically non-existent VEGF-C expression and insignificant differences in both VEGF-D immunohistoscore and peritumoral LVD among patients with non-recurrent, primary-to-recur and recurrent PAs are not in favor of the lymfangiogenic local spread hypothesis.
- Introduction: Recent research suggests that the multiplicity in recurrent pleomorphic adenoma (PA) might result from migration of its cells through lymphatics. This process in malignancies is mediated by vascular endothelial factors C and D (VEGF-C/D). Authors present very first study investigating immunohistoexpression of VEGF-C/D and lymphatic vessel density (LVD) in PA. Materials&Methods: Six non-recurrent, 4 primary-to-recur and 10 recurrent PAs were stained. The histoscore was calculated as a sum of staining intensity (0=absent to 3=strong) and the percentage of positive tumor cells (scored as 0 (0-19 %), 1 (20-39%), 2 (40-50%) and 3 (60-100%)). Intra- and peritumoral LVD was assessed using D2-40 antibody. Results: All but one sample were VEGF-C negative. The differences in VEGF-D histoscore among non-recurrent, primary-to-recur, and recurrent PAs were not significant (p>0.05). The VEGF-D histoscore didn’t correlate with peritumoral LVD (p>0.05). Our study revealed a significant difference between intra- and peritumoral LVD values when comparing individual and all sample groups (p=0.01). Conclusion: Practically non-existent VEGF-C expression and insignificant differences in both VEGF-D immunohistoscore and peritumoral LVD among patients with non-recurrent, primary-to-recur and recurrent PAs are not in favor of the lymfangiogenic local spread hypothesis. (en)
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| Title
| - Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor.
- Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor. (en)
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| skos:prefLabel
| - Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor.
- Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor. (en)
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| skos:notation
| - RIV/00098892:_____/13:#0000559!RIV14-MZ0-00098892
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00098892:_____/13:#0000559
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - lymphangiogenesis, local tumour spread (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| issn
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| number of pages
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