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  • Anthocyanins are pigments present in fruit and vegetables. Antocyanins are glycosides; their aglycones are flavonoids, anthocyanidins (the most common are cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin). In this preliminary report the inhibition of three forms of human liver microsomal CYPs was studied. The CYP3A4 activity was influenced the most being inhibited to about 60% of the original activity by most of the anthocyanins at the highest concentration tested.. Inhibition of CYP2C9 enzyme activity was more prominent with delphinidin-3-glucoside and cyanidin-3-galactoside (down to 60 % of the original activity), CYP1A2 enzyme was inhibited in a small extent. The results indicate that the interactions of anthocyanins with liver CYP enzymes most probably does not pose any harm to human organism based on drug interactions; however, in case of drugs metabolized by CYP3A4, and an ingestion of large amounts of anthocyanins, a limited increase of drug bioavailability may be observed however probably not clinically significant.
  • Anthocyanins are pigments present in fruit and vegetables. Antocyanins are glycosides; their aglycones are flavonoids, anthocyanidins (the most common are cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin). In this preliminary report the inhibition of three forms of human liver microsomal CYPs was studied. The CYP3A4 activity was influenced the most being inhibited to about 60% of the original activity by most of the anthocyanins at the highest concentration tested.. Inhibition of CYP2C9 enzyme activity was more prominent with delphinidin-3-glucoside and cyanidin-3-galactoside (down to 60 % of the original activity), CYP1A2 enzyme was inhibited in a small extent. The results indicate that the interactions of anthocyanins with liver CYP enzymes most probably does not pose any harm to human organism based on drug interactions; however, in case of drugs metabolized by CYP3A4, and an ingestion of large amounts of anthocyanins, a limited increase of drug bioavailability may be observed however probably not clinically significant. (en)
Title
  • Interaction of anthocyanins with human liver microsomal cytochromes P450
  • Interaction of anthocyanins with human liver microsomal cytochromes P450 (en)
skos:prefLabel
  • Interaction of anthocyanins with human liver microsomal cytochromes P450
  • Interaction of anthocyanins with human liver microsomal cytochromes P450 (en)
skos:notation
  • RIV/00098892:_____/13:#0000548!RIV14-MZ0-00098892
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • Suppl. 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 80634
http://linked.open...ai/riv/idVysledku
  • RIV/00098892:_____/13:#0000548
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • anthocyanins, cyanidin, malvidin, peonidin, petunidin, delphinidin, pelargonidin, human liver microsomes, cytochrome P45 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [1989FF6208FE]
http://linked.open...i/riv/nazevZdroje
  • Biomedical Papers-Olomouc
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 157
http://linked.open...iv/tvurceVysledku
  • Anzenbacher, Pavel
issn
  • 1213-8118
number of pages
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