About: MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review)

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About: MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Meningiomas represent one of the most common types of primary intracranial tumours. However, the specific molecular mechanisms underlying their pathogenesis remain uncertain. Loss of chromosomes 22q, 1p, and 14q have been implicated in most meningiomas. Inactivation of the NF2 gene at 22q12 has been identified as an early event in their pathogenesis, whereas abnormalities of chromosome 14 have been reported in higher-grade as well as recurrent tumours. It has long been supposed that chromosome 14q32 contains a tumour suppressor gene. However, the identity of the potential 14q32 tumour suppressor remained elusive until the Maternally Expressed Gene 3 (MEG3) was recently suggested as an ideal candidate. MEG3 is an imprinted gene located at 14q32 that encodes a non-coding RNA (ncRNA). In meningiomas, loss of MEG3 expression, its genomic DNA deletion and degree of promoter methylation have been found to be associated with aggressive tumour growth. These findings indicate that MEG3 may have a significant role as a novel long noncoding RNA tumour suppressor in meningiomas Meningiomas represent one of the most common types of primary intracranial tumours. However, the specific molecular mechanisms underlying their pathogenesis remain uncertain. Loss of chromosomes 22q, 1p, and 14q have been implicated in most meningiomas. Inactivation of the NF2 gene at 22q12 has been identified as an early event in their pathogenesis, whereas abnormalities of chromosome 14 have been reported in higher-grade as well as recurrent tumours. It has long been supposed that chromosome 14q32 contains a tumour suppressor gene. However, the identity of the potential 14q32 tumour suppressor remained elusive until the Maternally Expressed Gene 3 (MEG3) was recently suggested as an ideal candidate. MEG3 is an imprinted gene located at 14q32 that encodes a non-coding RNA (ncRNA). In meningiomas, loss of MEG3 expression, its genomic DNA deletion and degree of promoter methylation have been found to be associated with aggressive tumour growth. These findings indicate that MEG3 may have a significant role as a novel long noncoding RNA tumour suppressor in meningiomas (en)
Title	MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review) MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review) (en)
skos:prefLabel	MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review) MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review) (en)
skos:notation	RIV/00098892:_____/13:#0000427!RIV14-MZ0-00098892
http://linked.open...avai/predkladatel	Fakultní nemocnice Olomouc
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	SROVNAL, Josef Kalita, Ondřej Balík, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Olomouc
http://linked.open...dnocenehoVysledku	87142
http://linked.open...ai/riv/idVysledku	RIV/00098892:_____/13:#0000427
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA, retinoblastoma protein, tumor suppressor protein, untranslated RNA (en)
http://linked.open.../riv/klicoveSlovo	retinoblastoma protein tumor suppressor protein untranslated RNA microRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7BA32E2358EA]
http://linked.open...i/riv/nazevZdroje	Journal of Neuro-Oncology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	112
http://linked.open...iv/tvurceVysledku	Kalita, Ondřej Srovnal, Josef Balik, Vladimír
issn	0167-594X
number of pages	8 (xsd:int)

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