About: The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ibimapublishing.com/journals/IMMU/2013/119348/119348.pdf
Description	The article gives overview of both surface and intracellular markers present on T regulatory lymphocytes. Regulatory T cells (Tregs) play a proncipal role in immune reactions including autoimmunity, transplantation tolerance, anti-infectious immunity and cancer. Today the most widely accepted phenotype for Tregs is the coexpression of CD4, CD25 and FoxP3. But FoxP3 is an intracellular molecule, detection of which requires, fixation and permeabilization of cells and the fixed cells cannot be used in studies of Treg function. Moreover intracellular FofP3 staining is hardly usable on a daily clinical routine basis. Therefore several attempts have been characterize TRgs according their surface molecules. The particular molecules like CD25, CD127, CD26, CD39, CD45RA, CD49d, CD101, CD194 are described and their significance for distinguishing T regulatory lymphocytes from other T cells is discussed. Recently described surface molecule CD26 is another negative marker which seems to improve our possibilities in distinguishing this important popilation from effector T cells The article gives overview of both surface and intracellular markers present on T regulatory lymphocytes. Regulatory T cells (Tregs) play a proncipal role in immune reactions including autoimmunity, transplantation tolerance, anti-infectious immunity and cancer. Today the most widely accepted phenotype for Tregs is the coexpression of CD4, CD25 and FoxP3. But FoxP3 is an intracellular molecule, detection of which requires, fixation and permeabilization of cells and the fixed cells cannot be used in studies of Treg function. Moreover intracellular FofP3 staining is hardly usable on a daily clinical routine basis. Therefore several attempts have been characterize TRgs according their surface molecules. The particular molecules like CD25, CD127, CD26, CD39, CD45RA, CD49d, CD101, CD194 are described and their significance for distinguishing T regulatory lymphocytes from other T cells is discussed. Recently described surface molecule CD26 is another negative marker which seems to improve our possibilities in distinguishing this important popilation from effector T cells (en)
Title	The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes (en)
skos:prefLabel	The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes (en)
skos:notation	RIV/00064203:_____/13:10210476!RIV14-MZ0-00064203
http://linked.open...avai/predkladatel	Fakultní nemocnice v Motole
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	neuveden
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Lašťovička, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	96042
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/13:10210476
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FoxP3; surface markers; Treg; T regulatory lymphocytes (en)
http://linked.open.../riv/klicoveSlovo	T regulatory lymphocytes surface markers Treg FoxP3
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5340FE77B4B4]
http://linked.open...i/riv/nazevZdroje	Research in Immunology: An International Journal
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2013
http://linked.open...iv/tvurceVysledku	Lašťovička, Jan
issn	2331-7299
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.5171/2013.119348

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