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  • In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main cause of death. Treatment of lung disease to reduce the impact of infection, inflammation and subsequent lung injury is therefore of major importance. Here we discuss the present status of antibiotic therapy for the Major pathogens in CF airways, including prophylaxis against infection, eradication of early infection, suppression of chronic infection, and the treatment of infective exacerbations. We outline measures to optimize maintenance treatment for infection in the light of novel antibiotic drug formulations. We discuss new developments in culture-independent microbiological diagnostic techniques and the use of tools for monitoring the success of antibiotic treatment courses. Finally, cost-effectiveness analyses for antibiotic treatment in CF patients are discussed. (C) 2012 European Cystic Fibrosis Society.
  • In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main cause of death. Treatment of lung disease to reduce the impact of infection, inflammation and subsequent lung injury is therefore of major importance. Here we discuss the present status of antibiotic therapy for the Major pathogens in CF airways, including prophylaxis against infection, eradication of early infection, suppression of chronic infection, and the treatment of infective exacerbations. We outline measures to optimize maintenance treatment for infection in the light of novel antibiotic drug formulations. We discuss new developments in culture-independent microbiological diagnostic techniques and the use of tools for monitoring the success of antibiotic treatment courses. Finally, cost-effectiveness analyses for antibiotic treatment in CF patients are discussed. (C) 2012 European Cystic Fibrosis Society. (en)
Title
  • Treatment of lung infection in patients with cystic fibrosis: Current and future strategies
  • Treatment of lung infection in patients with cystic fibrosis: Current and future strategies (en)
skos:prefLabel
  • Treatment of lung infection in patients with cystic fibrosis: Current and future strategies
  • Treatment of lung infection in patients with cystic fibrosis: Current and future strategies (en)
skos:notation
  • RIV/00064203:_____/12:8746!RIV13-MZ0-00064203
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 6
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http://linked.open...aciTvurceVysledku
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  • 175047
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  • RIV/00064203:_____/12:8746
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pseudomonas-aeruginosa infection; resistant staphylococcus-aureus; inhaled aztreonam lysine; allergic bronchopulmonary aspergillosis; tobramycin inhalation powder; randomized controlled-trial; young-children; pulmonary-function; double-blind; stenotrophomonas-maltophilia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [4D7968969F21]
http://linked.open...i/riv/nazevZdroje
  • Journal of Cystic Fibrosis
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 11
http://linked.open...iv/tvurceVysledku
  • Bush, A.
  • Dřevínek, Pavel
  • Hjelte, L.
  • Hoiby, N.
  • Konstan, MW
  • Pressler, T.
  • Ramsey, BW
  • Ratjen, F.
  • Tullis, E.
  • Wainwright, CE
  • Cattaneo, A.
  • Goldman, M.
  • Bilton, D.
  • Gartner, S.
  • Angyalosi, G.
  • Assael, B.
  • Bell, S.
  • Campbell, PW
  • Dembowsky, K.
  • Doering, G.
  • Dubois, C.
  • Eichler, I.
  • Elborn, J.
  • Flume, P.
  • Foweraker, J. E
  • Gallagher, C.
  • Geller, D. E.
  • Goss, C. H.
  • Gupta, R.
  • Heijerman, H.
  • Henig, N.
  • Higgins, M.
  • Jongejan, R.
  • Knoch, M.
  • Muhlebach, MS
  • Nieuwenhuizen, PW
  • Parkins, MD
  • Quittner, A. L.
  • Smyth, A.
  • Thieroff-Ekerdt, R.
  • Vazquez, C.
  • de Boeck, K.
  • van der Ent, CK
http://linked.open...ain/vavai/riv/wos
  • 000312115900001
issn
  • 1569-1993
number of pages
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