About: Bone grafts as vancomycin carriers in local therapy of resistant infections

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s12223-011-0093-2
Description	The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to what extent vancomycin (Van) bound to ground bone grafts is usable in the treatment of serious infections. The levels of released Van significantly exceeded the Van minimum inhibitory concentration, which can suppress Van-sensitive staphylococci and Van intermediate Staphylococcus aureus, for the whole period of a 16-day measurement. Our results indicate that bone grafts can be used as Van carriers in therapy of osteomyelitis caused by Van-sensitive Staphylococcus strains. The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to what extent vancomycin (Van) bound to ground bone grafts is usable in the treatment of serious infections. The levels of released Van significantly exceeded the Van minimum inhibitory concentration, which can suppress Van-sensitive staphylococci and Van intermediate Staphylococcus aureus, for the whole period of a 16-day measurement. Our results indicate that bone grafts can be used as Van carriers in therapy of osteomyelitis caused by Van-sensitive Staphylococcus strains. (en)
Title	Bone grafts as vancomycin carriers in local therapy of resistant infections Bone grafts as vancomycin carriers in local therapy of resistant infections (en)
skos:prefLabel	Bone grafts as vancomycin carriers in local therapy of resistant infections Bone grafts as vancomycin carriers in local therapy of resistant infections (en)
skos:notation	RIV/00064203:_____/12:8261!RIV13-MZ0-00064203
http://linked.open...avai/predkladatel	Fakultní nemocnice v Motole
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jahoda, David Klapková, Eva Barták, Vladislav Sosna, Antonín Pokorný, David Nyč, Otakar Melicherčík, Pavel Landor, Ivan Judl, Tobiáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	125369
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8261
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	late hematogenous infection; staphylococcus-aureus; in-vitro; clinical-use; antibiotics; allograft; release (en)
http://linked.open.../riv/klicoveSlovo	allograft late hematogenous infection staphylococcus-aureus antibiotics release clinical-use in-vitro
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[598E79F655EC]
http://linked.open...i/riv/nazevZdroje	Folia Microbiologica
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Barták, Vladislav Jahoda, David Klapková, Eva Nyč, Otakar Sosna, Antonín Pokorný, David Judl, Tobiáš Landor, Ivan Melicherčík, Pavel
http://linked.open...ain/vavai/riv/wos	000307509300011
issn	0015-5632
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Bone grafts as vancomycin carriers in local therapy of resistant infections

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