About: HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants

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About: HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22691100
Description	Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the general Norwegian population, 190 healthy infants at high-risk for T1D (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB106:02), or were neutral (all other genotypes). A total of 4626 monthly fecal samples taken between age 3 and 12mo were tested for enterovirus RNA using real-time PCR. Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other children (adjusted odds ratio: 1.23, p = 0.12). The prevalence was 11.3% in those with increased-to-moderate risk, 13.0% in the protective group, and 12.6% in the neutral group (likelihood ratio test, 3 d.f.: p = 0.37). In conclusion, there was no statistically significant association between HLA genotype and the occurrence of human enterovirus gut infections. Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the general Norwegian population, 190 healthy infants at high-risk for T1D (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB106:02), or were neutral (all other genotypes). A total of 4626 monthly fecal samples taken between age 3 and 12mo were tested for enterovirus RNA using real-time PCR. Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other children (adjusted odds ratio: 1.23, p = 0.12). The prevalence was 11.3% in those with increased-to-moderate risk, 13.0% in the protective group, and 12.6% in the neutral group (likelihood ratio test, 3 d.f.: p = 0.37). In conclusion, there was no statistically significant association between HLA genotype and the occurrence of human enterovirus gut infections. (en)
Title	HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants (en)
skos:prefLabel	HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants (en)
skos:notation	RIV/00064203:_____/12:8106!RIV13-MZ0-00064203
http://linked.open...avai/predkladatel	Fakultní nemocnice v Motole
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT11465)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Cinek, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	139209
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8106
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dependent diabetes-mellitus; beta-cell autoimmunity; encephalomyocarditis virus; young daisy; hla; infections; risk; iddm; genetics; antigens (en)
http://linked.open.../riv/klicoveSlovo	genetics risk antigens dependent diabetes-mellitus encephalomyocarditis virus hla young daisy iddm infections beta-cell autoimmunity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B98EC0F04FF4]
http://linked.open...i/riv/nazevZdroje	Viral Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Selected picornaviruses in the pathogenesis of islet autoimmunity and type 1 diabetes
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Cinek, Ondřej Stene, LC Rasmussen, T. Ronningen, KS Tapia, G. Witso, E.
http://linked.open...ain/vavai/riv/wos	000305285000003
issn	0882-8245
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants

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