About: A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption

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About: A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1515/CCLM.2011.781
Description	To investigate the mechanism by which strontium ranelate (SrR) inhibits the bone resorption, this study compared the effects of SrR and calcium on parathyroid hormone (PTH) and the biochemical marker of bone resorption (serum type I collagen cross-linked C-telopepticle, beta CTX). Methods: In 10 healthy young subjects, after overnight fasting, 1000 mg of elemental calcium and 2000 mg of SrR containing 600 mg Sr2+ were administered consecutively with a 1 week washout period. During the control period no drug was given. Fasting blood samples were drawn at baseline and throughout the next 5-h period. Results: After the ingestion of either calcium or SrR, there was a significant increase in serum calcium and strontium concentrations, and a decrease in serum beta CTX and intact PTH concentrations as compared to the baseline values (p<0.05). In the fasting subjects, no significant differences in the variable were found as compared to the baseline values. Conclusions: The decrease in PTH and the marker of bone resorption observed after the SrR administration is comparable to the decrease observed after the calcium administration in young adults. To investigate the mechanism by which strontium ranelate (SrR) inhibits the bone resorption, this study compared the effects of SrR and calcium on parathyroid hormone (PTH) and the biochemical marker of bone resorption (serum type I collagen cross-linked C-telopepticle, beta CTX). Methods: In 10 healthy young subjects, after overnight fasting, 1000 mg of elemental calcium and 2000 mg of SrR containing 600 mg Sr2+ were administered consecutively with a 1 week washout period. During the control period no drug was given. Fasting blood samples were drawn at baseline and throughout the next 5-h period. Results: After the ingestion of either calcium or SrR, there was a significant increase in serum calcium and strontium concentrations, and a decrease in serum beta CTX and intact PTH concentrations as compared to the baseline values (p<0.05). In the fasting subjects, no significant differences in the variable were found as compared to the baseline values. Conclusions: The decrease in PTH and the marker of bone resorption observed after the SrR administration is comparable to the decrease observed after the calcium administration in young adults. (en)
Title	A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption (en)
skos:prefLabel	A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption (en)
skos:notation	RIV/00064203:_____/12:8003!RIV13-MZ0-00064203
http://linked.open...avai/predkladatel	Fakultní nemocnice v Motole
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Franěk, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	120099
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/12:8003
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bone markers; calcium; collagen type I; strontium ranelate; sensing receptor; i collagen; osteoporosis; telopeptides; osteoclasts; crosslaps; women (en)
http://linked.open.../riv/klicoveSlovo	collagen type I strontium ranelate osteoclasts crosslaps i collagen sensing receptor telopeptides women calcium osteoporosis bone markers
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[2E9D6A3FCEAA]
http://linked.open...i/riv/nazevZdroje	Clinical Chemistry and Laboratory Medicine
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Franěk, Tomáš Maresova, KB Stepan, JJ Vondráček, T.
http://linked.open...ain/vavai/riv/wos	000301991300018
issn	1434-6621
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption

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