About: Antiepileptic drug interactions: A clinical case demonstration

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.medvik.cz/link/bmc11034501
Description	Epilepsy is a serious health disorder affecting both paediatric and adult population worldwide. Due to difficulties in identifying its aetiology, initial management is often guided by empiric therapy measures. Symptomatic control requires the use of antiepileptic drugs (AEDs), many of which have the potential for adverse drug interactions. Children are especially susceptible to drug interactions and frequently exhibit atypical adverse events, which may require special care. Aim. To demonstrate a case of a 15 year old girl suffering from refractory epilepsy with underlying focal cortical dysplasia (FCD), whose seizure deterioration was most probably associated with drug-drug interactions between prescribed common antiepileptic drugs, namely valproic acid, phenobarbital or the prodrug primidon and carbamazepine. Epilepsy is a serious health disorder affecting both paediatric and adult population worldwide. Due to difficulties in identifying its aetiology, initial management is often guided by empiric therapy measures. Symptomatic control requires the use of antiepileptic drugs (AEDs), many of which have the potential for adverse drug interactions. Children are especially susceptible to drug interactions and frequently exhibit atypical adverse events, which may require special care. Aim. To demonstrate a case of a 15 year old girl suffering from refractory epilepsy with underlying focal cortical dysplasia (FCD), whose seizure deterioration was most probably associated with drug-drug interactions between prescribed common antiepileptic drugs, namely valproic acid, phenobarbital or the prodrug primidon and carbamazepine. (en)
Title	Antiepileptic drug interactions: A clinical case demonstration Antiepileptic drug interactions: A clinical case demonstration (en)
skos:prefLabel	Antiepileptic drug interactions: A clinical case demonstration Antiepileptic drug interactions: A clinical case demonstration (en)
skos:notation	RIV/00064203:_____/11:7239!RIV12-MZ0-00064203
http://linked.open...avai/predkladatel	Fakultní nemocnice v Motole
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Tesfayeová, Alena Klapková, Eva Komárek, Vladimír Tesfaye, Hundie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	186441
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/11:7239
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	focal cortical dysplasia; refractory epilepsy drug; drug interaction (en)
http://linked.open.../riv/klicoveSlovo	drug interaction focal cortical dysplasia refractory epilepsy drug
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B2CE81575268]
http://linked.open...i/riv/nazevZdroje	Časopis lékařů českých
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	150
http://linked.open...iv/tvurceVysledku	Klapková, Eva Komárek, Vladimír Tesfaye, Hundie Tesfayeová, Alena
issn	0008-7335
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Antiepileptic drug interactions: A clinical case demonstration Antiepileptic drug interactions: A clinical case demonstration

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