About: Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid COJEC Induction in Pediatric Patients With High-Risk Neuroblastoma: The European HR-NBL1/SIOPEN Study     Goto   Sponge   NotDistinct   Permalink

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  • To reduce the incidence of febrile neutropenia during rapid COJEC (cisplatin, vincristine, carboplatin, etoposide, and cyclophosphamide given in a rapid delivery schedule) induction. In the High-Risk Neuroblastoma-1 (HR-NBL1) trial, the International Society of Paediatric Oncology European Neuroblastoma Group (SIOPEN) randomly assigned patients to primary prophylactic (PP) versus symptom-triggered granulocyte colony-stimulating factor (GCSF; filgrastim). Chemotherapy was administered every 10 days regardless of hematologic recovery, provided that infection was controlled. Results The PPGCSF arm had significantly fewer febrile neutropenic episodes (P = .002), days with fever (P = .004), hospital days (P = .017), and antibiotic days (P = .001). Conclusion Following these results, PPG-GSF was advised for all patients on rapid COJEC induction.
  • To reduce the incidence of febrile neutropenia during rapid COJEC (cisplatin, vincristine, carboplatin, etoposide, and cyclophosphamide given in a rapid delivery schedule) induction. In the High-Risk Neuroblastoma-1 (HR-NBL1) trial, the International Society of Paediatric Oncology European Neuroblastoma Group (SIOPEN) randomly assigned patients to primary prophylactic (PP) versus symptom-triggered granulocyte colony-stimulating factor (GCSF; filgrastim). Chemotherapy was administered every 10 days regardless of hematologic recovery, provided that infection was controlled. Results The PPGCSF arm had significantly fewer febrile neutropenic episodes (P = .002), days with fever (P = .004), hospital days (P = .017), and antibiotic days (P = .001). Conclusion Following these results, PPG-GSF was advised for all patients on rapid COJEC induction. (en)
Title
  • Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid COJEC Induction in Pediatric Patients With High-Risk Neuroblastoma: The European HR-NBL1/SIOPEN Study
  • Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid COJEC Induction in Pediatric Patients With High-Risk Neuroblastoma: The European HR-NBL1/SIOPEN Study (en)
skos:prefLabel
  • Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid COJEC Induction in Pediatric Patients With High-Risk Neuroblastoma: The European HR-NBL1/SIOPEN Study
  • Randomized Trial of Prophylactic Granulocyte Colony-Stimulating Factor During Rapid COJEC Induction in Pediatric Patients With High-Risk Neuroblastoma: The European HR-NBL1/SIOPEN Study (en)
skos:notation
  • RIV/00064203:_____/10:6303!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 283882
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/10:6303
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acute lymphoblastic-leukemia; receiving myelosuppressive chemotherapy; non-hodgkins-lymphoma; febrile neutropenia; stage-4 neuroblastoma; oncology-group; metastatic neuroblastoma; daily filgrastim; children older; growth-factors (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [F7DE1EBDEF42]
http://linked.open...i/riv/nazevZdroje
  • Journal of Clinical Oncology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 28
http://linked.open...iv/tvurceVysledku
  • Ladenstein, R.
  • Potschger, U.
  • Garami, M.
  • Schroeder, H.
  • Valteau-Couanet, D.
  • Mališ, Josef
  • Balwierz, W.
  • Beck-Popovic, M.
  • Brock, P.
  • Castel, V.
  • Kogner, P.
  • Lacerda, A.
  • Laureys, G.
  • Machin, D.
  • Papadakis, V.
  • Pearson, A.
  • Ruud, E.
  • Schreier, G.
  • Yaniv, I.
http://linked.open...ain/vavai/riv/wos
  • 000280003700018
issn
  • 0732-183X
number of pages
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