About: Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol     Goto   Sponge   NotDistinct   Permalink

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  • We aimed at characterizing the pharmacokinetics for daunorubicin in infants with ALL and examined their relationship to age, body weight, and body surface area. No age-dependency in any of the BSA-normalized pharmacokinetic parameters was observed. Consequently, due to the empirical dose reduction in infants the overall exposure to daunorubicinol in infants was smaller than would be expected from older children. We observed no indication of an age-dependency in the pharmacokinetics of daunorubicin.
  • We aimed at characterizing the pharmacokinetics for daunorubicin in infants with ALL and examined their relationship to age, body weight, and body surface area. No age-dependency in any of the BSA-normalized pharmacokinetic parameters was observed. Consequently, due to the empirical dose reduction in infants the overall exposure to daunorubicinol in infants was smaller than would be expected from older children. We observed no indication of an age-dependency in the pharmacokinetics of daunorubicin. (en)
Title
  • Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol
  • Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol (en)
skos:prefLabel
  • Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol
  • Pharmacokinetics of Daunorubicin and Daunorubicinol in Infants With Leukemia Treated in the Interfant 99 Protocol (en)
skos:notation
  • RIV/00064203:_____/10:6069!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 278711
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/10:6069
http://linked.open...riv/jazykVysledku
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  • daunorubicin; infants; leukemia; pharmacokinetics; acute lymphoblastic-leukemia; risk-factors; model; therapy; cardiotoxicity; quantification; doxorubicin; ly335979 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [2CE408195166]
http://linked.open...i/riv/nazevZdroje
  • Pediatric Blood & Cancer
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Pieters, R.
  • Starý, Jan
  • De Lorenzo, P.
  • Valsecchi, MG
  • Hempel, G.
  • Barisone, E.
  • Boos, J.
  • Relling, M. V.
  • de Rossi, G.
http://linked.open...ain/vavai/riv/wos
  • 000274421400006
issn
  • 1545-5009
number of pages
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