About: Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients. Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients. (en)
Title	Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis (en)
skos:prefLabel	Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis (en)
skos:notation	RIV/00064173:_____/13:#0000338!RIV14-MZ0-00064173
http://linked.open...avai/predkladatel	Fakultní nemocnice Královské Vinohrady
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT13183)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kotoučová, Jolana Zimová, Denisa Bartoš, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	104776
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/13:#0000338
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Serum; Multiple sclerosis; Heavy neurofllament; Clinically isolated syndrome; Cerebrospinal fluid; Antibody (en)
http://linked.open.../riv/klicoveSlovo	Clinically isolated syndrome Heavy neurofllament Cerebrospinal fluid Multiple sclerosis Serum Antibody
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FEB5706EF545]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroimmunology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Brief psychometric instruments for early diagnosis of Alzheimer's disease in senior population
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	259
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Zimová, Denisa Kotoučová, Jolana
http://linked.open...ain/vavai/riv/wos	000319848100010
issn	0165-5728
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jneuroim.2013.03.009

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