About: Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation     Goto   Sponge   NotDistinct   Permalink

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  • Non-rheumatic, calcified aortic valve stenosis (CAS) is the most frequent valvular heart disease in adults, and carries substantial morbidity and mortality. Thus, aortic valve replacement is the most commonly performed valve intervention in the adult population. The main pathognomonic sign of valve degeneration (both – native and bioprosthesis) is progressive valve calcification. The presence of aortic valve calcium in patients with asymptomatic mild or moderate CAS has been recognized as the single most significant predictor of clinical progression. The most intriguing observation of this study is that the dynamics of the circulating regulators of osteoblastic and osteoclastic activity, OPG and Dkk-1, differ significantly in relation to the mode of aortic valve repair. The substantial difference was observed in circulating regulators of osteoblastic and osteoclastic activity, i.e. OPG and Dkk-1, in relation to the mode of valve repair in patients with CAS. New studies are needed to determine if these changes are associated with differential degeneration of aortic valve bioprostheses.
  • Non-rheumatic, calcified aortic valve stenosis (CAS) is the most frequent valvular heart disease in adults, and carries substantial morbidity and mortality. Thus, aortic valve replacement is the most commonly performed valve intervention in the adult population. The main pathognomonic sign of valve degeneration (both – native and bioprosthesis) is progressive valve calcification. The presence of aortic valve calcium in patients with asymptomatic mild or moderate CAS has been recognized as the single most significant predictor of clinical progression. The most intriguing observation of this study is that the dynamics of the circulating regulators of osteoblastic and osteoclastic activity, OPG and Dkk-1, differ significantly in relation to the mode of aortic valve repair. The substantial difference was observed in circulating regulators of osteoblastic and osteoclastic activity, i.e. OPG and Dkk-1, in relation to the mode of valve repair in patients with CAS. New studies are needed to determine if these changes are associated with differential degeneration of aortic valve bioprostheses. (en)
Title
  • Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation
  • Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation (en)
skos:prefLabel
  • Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation
  • Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation (en)
skos:notation
  • RIV/00064173:_____/12:43897447!RIV13-MZ0-00064173
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NT13711)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 127255
http://linked.open...ai/riv/idVysledku
  • RIV/00064173:_____/12:43897447
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Transcatheter aortic valve implantation; Aortic valve replacement; RANKL/OPG/Dkk-1; Calcified aortic valve stenosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IE - Irsko
http://linked.open...ontrolniKodProRIV
  • [0511B03905E5]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Cardiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 158
http://linked.open...iv/tvurceVysledku
  • Toušek, Petr
  • Widimský, Petr
  • Moťovská, Zuzana
  • Víchová, Teodora
http://linked.open...ain/vavai/riv/wos
  • 000305273000032
issn
  • 0167-5273
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.ijcard.2012.04.115
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