About: Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases     Goto   Sponge   NotDistinct   Permalink

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  • Autologous hematopoietic stem cell transplantation has been used since 1996 for the treatment of severe autoimmune diseases refractory to approved therapies. We evaluated the long-term outcomes of these transplants and aimed to identify potential prognostic factors. Methods: In this observational study we analyzed all first autologous hematopoietic stem cell trans plants for autoimmune diseases reported to the European Group for Blood and Marrow Transplantation (EBMT) registry between 1996-2007. The primary end-points for analysis were overall survival, progression-free survival and trans plant-related mortality at 100 days. Results improved with time and were associated with the transplant centers' experience. These data support ongoing and planned phase III trials to evaluate the place of autologous hematopoietic stem cell transplantation in the treatment strategy for severe autoimmune diseases.
  • Autologous hematopoietic stem cell transplantation has been used since 1996 for the treatment of severe autoimmune diseases refractory to approved therapies. We evaluated the long-term outcomes of these transplants and aimed to identify potential prognostic factors. Methods: In this observational study we analyzed all first autologous hematopoietic stem cell trans plants for autoimmune diseases reported to the European Group for Blood and Marrow Transplantation (EBMT) registry between 1996-2007. The primary end-points for analysis were overall survival, progression-free survival and trans plant-related mortality at 100 days. Results improved with time and were associated with the transplant centers' experience. These data support ongoing and planned phase III trials to evaluate the place of autologous hematopoietic stem cell transplantation in the treatment strategy for severe autoimmune diseases. (en)
Title
  • Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases
  • Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases (en)
skos:prefLabel
  • Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases
  • Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases (en)
skos:notation
  • RIV/00064173:_____/10:00002653!RIV13-MZ0-00064173
http://linked.open...avai/riv/aktivita
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  • 248154
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  • RIV/00064173:_____/10:00002653
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  • hematologic immune cytopenia; juvenile idiopathic arthritis; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; multiple sclerosis; autoimmune diseases; autologous hematopoietic stem cell transplantation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IT - Italská republika
http://linked.open...ontrolniKodProRIV
  • [5FEE14C95A3C]
http://linked.open...i/riv/nazevZdroje
  • Haematologica - The Hematology Journal
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 95
http://linked.open...iv/tvurceVysledku
  • Kozák, Tomáš
http://linked.open...ain/vavai/riv/wos
  • 000274803700017
issn
  • 0390-6078
number of pages
http://bibframe.org/vocab/doi
  • 10.3324/haematol.2009.013458
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