About: Modeling new therapies for infantile spasms

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	P>Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin-are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms. P>Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin-are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms. (en)
Title	Modeling new therapies for infantile spasms Modeling new therapies for infantile spasms (en)
skos:prefLabel	Modeling new therapies for infantile spasms Modeling new therapies for infantile spasms (en)
skos:notation	RIV/00064173:_____/10:00002546!RIV13-MZ0-00064173
http://linked.open...avai/riv/aktivita	N S
http://linked.open...avai/riv/aktivity	N, S
http://linked.open...iv/cisloPeriodika	Suppl. 3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Chudomelová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	271854
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:00002546
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rapamycin; mTOR; Vigabatrin; Adrenocorticotropic hormone; Models; Infantile spasms (en)
http://linked.open.../riv/klicoveSlovo	Rapamycin Adrenocorticotropic hormone mTOR Models Vigabatrin Infantile spasms
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[175800B37483]
http://linked.open...i/riv/nazevZdroje	Epilepsia
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Chudomelová, Lenka
http://linked.open...ain/vavai/riv/wos	000279442400005
issn	0013-9580
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1528-1167.2010.02605.x
is http://linked.open...avai/riv/vysledek of	Modeling new therapies for infantile spasms

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