About: Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models

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About: Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	P>Elevated levels of survivin, telomerase catalytic subunit (TERT), integrin-linked kinase (ILK), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS) and the regulatory factors c-MYB and Tcf-4 are often found in human cancers including colorectal cancer (CRC) and have been implicated in the development and progression of tumorigenesis. The aim of this study was to determine the expression of these genes in mouse models of sporadic and colitis-associated CRC. To address these issues, we used qRT-PCR approach to determine changes in gene expression patterns of neoplastic cells (high-grade dysplasia/intramucosal carcinoma) and surrounding normal epithelial cells in A/J and ICR mouse strains using laser microdissection. Both strains were injected with azoxymethane and ICR mice were also given drinking water that contained 2% dextran sodium sulphate. P>Elevated levels of survivin, telomerase catalytic subunit (TERT), integrin-linked kinase (ILK), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS) and the regulatory factors c-MYB and Tcf-4 are often found in human cancers including colorectal cancer (CRC) and have been implicated in the development and progression of tumorigenesis. The aim of this study was to determine the expression of these genes in mouse models of sporadic and colitis-associated CRC. To address these issues, we used qRT-PCR approach to determine changes in gene expression patterns of neoplastic cells (high-grade dysplasia/intramucosal carcinoma) and surrounding normal epithelial cells in A/J and ICR mouse strains using laser microdissection. Both strains were injected with azoxymethane and ICR mice were also given drinking water that contained 2% dextran sodium sulphate. (en)
Title	Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models (en)
skos:prefLabel	Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models (en)
skos:notation	RIV/00064173:_____/10:#0000050!RIV11-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1A8651), P(NS9982), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kment, M. Bendová, M.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	258534
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:#0000050
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colon cancer, gene expression, mouse (en)
http://linked.open.../riv/klicoveSlovo	gene expression colon cancer mouse
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[22013D250C70]
http://linked.open...i/riv/nazevZdroje	International Journal of Experimental Pathology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	New markers of development of colorectal carcinoma in ulcerative colitis patients Predictive molecular markers of colorectal cancer development
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	91
http://linked.open...iv/tvurceVysledku	Švec, J. Pácha, J. Mandys, Václav Kment, Milan Ergang, P.
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0959-9673
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models

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