About: Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://fb.cuni.cz/file/5577/FB2011A0013.pdf
Description	Pregnant women are often threatened by hypertension, symptoms of preterm labor, hepatopathy and other. These complications might be consequence of genetic factors together with involvement of enviromental factors. We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exon 5 and 7 of the Pregnancy associated plasma protein-A gene in the studied group consisted of 203 women – 79 pregnant women in time of preterm labor, 24 pregnant women suffering from preeclampsia and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of all studied groups, which lead us to the hypothesis, that these polymorphisms are not associated with our studied group of Caucasian origin. However further studies with larger group of studied subjects are needed to confirm our results. Pregnant women are often threatened by hypertension, symptoms of preterm labor, hepatopathy and other. These complications might be consequence of genetic factors together with involvement of enviromental factors. We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exon 5 and 7 of the Pregnancy associated plasma protein-A gene in the studied group consisted of 203 women – 79 pregnant women in time of preterm labor, 24 pregnant women suffering from preeclampsia and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of all studied groups, which lead us to the hypothesis, that these polymorphisms are not associated with our studied group of Caucasian origin. However further studies with larger group of studied subjects are needed to confirm our results. (en)
Title	Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies (en)
skos:prefLabel	Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies (en)
skos:notation	RIV/00064165:_____/11:9456!RIV12-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Zdeněk Germanová, Anna Muravská, Alexandra Kalousová, Marta Jáchymová, Marie Zima, Tomáš Koucký, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	222909
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:9456
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	associated plasma protein-A; PAPP-A; pregnancy; preeclampsia; preterm labour; single nucleotide polymorphism; SNP; gene sequenation (en)
http://linked.open.../riv/klicoveSlovo	PAPP-A SNP single nucleotide polymorphism associated plasma protein-A gene sequenation preterm labour pregnancy preeclampsia
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[561A0C067153]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Germanová, Anna Hájek, Zdeněk Jáchymová, Marie Kalousová, Marta Zima, Tomáš Koucký, Michal Germanová, Alexandra
http://linked.open...ain/vavai/riv/wos	000290506000006
issn	0015-5500
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

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