About: The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new cytokeratin tumor marker, MonoTotal was studied in lung cancer, the most common cause of cancer mortality worldwide. In non-small cell lung cancer (NSCLC) patients MonoTotal serum levels and their relationship to the tumor stage, histological subtype, early relapse and cancer-related death were evaluated. Patients and Methods: MonoTotal serum levels were studied, using immunoradiometric assay in a group of 93 patients with newly diagnosed NSCLC undergoing radical surgery, and were compared to those with benign lung diseases. Results: A diagnostic power of MonoTotal in distinguishing patients with NSCLC from benign lung diseases was demonstrated. Higher levels of Mono Total were associated with advanced stages of squamous cell carcinoma and there was a positive correlation of marker with tumor size. Marker levels showed significant relation to disease-free survival and overall survival. Conclusion: MonoTotal seems to be a potentially very interesting serum marker that, in conjunction with other clinical data, might be used for monitoring of patients with NSCLC. A new cytokeratin tumor marker, MonoTotal was studied in lung cancer, the most common cause of cancer mortality worldwide. In non-small cell lung cancer (NSCLC) patients MonoTotal serum levels and their relationship to the tumor stage, histological subtype, early relapse and cancer-related death were evaluated. Patients and Methods: MonoTotal serum levels were studied, using immunoradiometric assay in a group of 93 patients with newly diagnosed NSCLC undergoing radical surgery, and were compared to those with benign lung diseases. Results: A diagnostic power of MonoTotal in distinguishing patients with NSCLC from benign lung diseases was demonstrated. Higher levels of Mono Total were associated with advanced stages of squamous cell carcinoma and there was a positive correlation of marker with tumor size. Marker levels showed significant relation to disease-free survival and overall survival. Conclusion: MonoTotal seems to be a potentially very interesting serum marker that, in conjunction with other clinical data, might be used for monitoring of patients with NSCLC. (en)
Title	The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC) The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC) (en)
skos:prefLabel	The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC) The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC) (en)
skos:notation	RIV/00064165:_____/11:9399!RIV12-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Svobodová, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	227471
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:9399
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MonoTotal; lung cancer; cytokeratins; tumour markers; tumor-markers (en)
http://linked.open.../riv/klicoveSlovo	MonoTotal cytokeratins tumor-markers lung cancer tumour markers
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[772BD99A8815]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Šafránek, Jarmil Holubec, Luboš Pešta, Martin Pražáková, Markéta Auge, Josep, Maria Fuchsová, Radka Spišáková, Markéta Svobodová, Šárka Topolčan, Ondrej Vrzalováindra, J.
http://linked.open...ain/vavai/riv/wos	000293357700060
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	0250-7005
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC) The role of monototal in the primary diagnosis, prognosis and follow-up of patients with non-small cell lung cancer (NSCLC)

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