About: Association of pregnancy-associated plasma protein A polymorphism with preeclampsia

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About: Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015
Description	The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results. The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results. (en)
Title	Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study (en)
skos:prefLabel	Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study (en)
skos:notation	RIV/00064165:_____/11:9362!RIV12-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika	17-18
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Zdeněk Germanová, Anna Švarcová, Jana Muravská, Alexandra Kalousová, Marta Jáchymová, Marie Zima, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	187337
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:9362
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Intrahepatic cholestasis of pregnancy; PAPP-A; Preeclampsia; Pregnancy-associated plasma protein A; Single nucleotide polymorphism; Gene; Intrauterine growth restriction; Preterm labor (en)
http://linked.open.../riv/klicoveSlovo	Intrahepatic cholestasis of pregnancy Intrauterine growth restriction PAPP-A Preeclampsia Pregnancy-associated plasma protein A Preterm labor Single nucleotide polymorphism Gene
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[BFAB14EA2129]
http://linked.open...i/riv/nazevZdroje	Clinical Biochemistry
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Germanová, Anna Hájek, Zdeněk Jáchymová, Marie Kalousová, Marta Muravská, Alexandra Zima, Tomáš Švarcová, Jana
http://linked.open...ain/vavai/riv/wos	000297570300004
http://linked.open...n/vavai/riv/zamer	Diagnosis and treatment of inherited disorders II
issn	0009-9120
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

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