About: Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats.

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About: Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.4149/endo_2010_04_165
Description	Objective: Rheumatoid arthritis (RA) is associated with enhanced pro-inflammatory cytokine levels, pain, anorexia, and cognitive changes. The enhanced production of cytokines appears before the full manifestation of the disease. So far, any experimental data on behavioral effects of early arthritis are lacking. In the present series we describe anorexia early changes in, pain hyper-sensitivity and altered cognitive behavior during the first four days of adjuvant arthritis in rats (AA), when no clinical signs are yet apparent. Conclusions: Early stage of AA brings about reduced body weight, food intake, and activation of central orexigenic pathways. The observed anorexia could be ascribed to the over-expression of anorexigenic IL-1? which dominates over the NPY orexigenic effects. On day 2 of AA higher pain sensitivity and cognitive impairment appear. All the observed change tend to recover by day 4 of the disease. Objective: Rheumatoid arthritis (RA) is associated with enhanced pro-inflammatory cytokine levels, pain, anorexia, and cognitive changes. The enhanced production of cytokines appears before the full manifestation of the disease. So far, any experimental data on behavioral effects of early arthritis are lacking. In the present series we describe anorexia early changes in, pain hyper-sensitivity and altered cognitive behavior during the first four days of adjuvant arthritis in rats (AA), when no clinical signs are yet apparent. Conclusions: Early stage of AA brings about reduced body weight, food intake, and activation of central orexigenic pathways. The observed anorexia could be ascribed to the over-expression of anorexigenic IL-1? which dominates over the NPY orexigenic effects. On day 2 of AA higher pain sensitivity and cognitive impairment appear. All the observed change tend to recover by day 4 of the disease. (en)
Title	Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. (en)
skos:prefLabel	Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. (en)
skos:notation	RIV/00064165:_____/11:10931!RIV12-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Běláček, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	235827
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/11:10931
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Early adjuvant arthritis; Anorexia; Neuropeptide Y; Interleukin 1beta; Hypothalamus; Hypernociception; Learning (en)
http://linked.open.../riv/klicoveSlovo	Learning Anorexia Early adjuvant arthritis Hypernociception Hypothalamus Interleukin 1beta Neuropeptide Y
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[C198ED9BF2F5]
http://linked.open...i/riv/nazevZdroje	Endocrine Regulations
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Pecha, Ondřej Kiss, A. Deykun, K. Běláček, Jaromír Jurcovicová, J. Skurlová, M. Stofková, A.
issn	1210-0668
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats. Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats.

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