About: Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objective of this study was to measure plasma fibroblast growth factor 21 and 19 (FGF21 and FGF19) levels in patients with Cushing's syndrome (CS) and to compare it with those of lean control subjects (C) and patients with obesity (OB). Fourteen untreated patients with CS, 19 patients with OB and 36 controls were included in the study. Plasma FGF19 did not significantly differ among the studied groups. Plasma FGF21 levels were significantly higher in both CS and OB groups relative to C group but they did not differ between CS and OB groups. In a combined population of all three groups FGF21 levels positively correlated with BMI, waist circumference and percentage of total and truncal fat mass. Less prominent inverse relationship with these parameters was found for FGF19. Neither FGF21 nor FGF19 were significantly related to cortisol concentrations. The objective of this study was to measure plasma fibroblast growth factor 21 and 19 (FGF21 and FGF19) levels in patients with Cushing's syndrome (CS) and to compare it with those of lean control subjects (C) and patients with obesity (OB). Fourteen untreated patients with CS, 19 patients with OB and 36 controls were included in the study. Plasma FGF19 did not significantly differ among the studied groups. Plasma FGF21 levels were significantly higher in both CS and OB groups relative to C group but they did not differ between CS and OB groups. In a combined population of all three groups FGF21 levels positively correlated with BMI, waist circumference and percentage of total and truncal fat mass. Less prominent inverse relationship with these parameters was found for FGF19. Neither FGF21 nor FGF19 were significantly related to cortisol concentrations. (en)
Title	Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome (en)
skos:prefLabel	Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome (en)
skos:notation	RIV/00064165:_____/10:6466!RIV11-MZ0-00064165
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR9438)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Zikán, Vít Matoulek, Martin Kaválková, Petra Lacinová, Zdeňka Haluzíková, Denisa Ďurovcová, Viktória Kršek, Michal Haluzík, Martin Hána, Václav Marek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	279109
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/10:6466
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Fibroblast growth factor 21; fibroblast growth factor 19; hypercortisolism; obesity; PPAR-alpha; metabolic regulator (en)
http://linked.open.../riv/klicoveSlovo	hypercortisolism obesity Fibroblast growth factor 21 PPAR-alpha fibroblast growth factor 19 metabolic regulator
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[242A73A7ED01]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Pathogenesis of insulin resistance in obesity and selected endocrinopathies, importance of endocrine activity of the adipose tissue and mitochondrial dysfunction
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Haluzík, Martin Kršek, Michal Marek, Josef Matoulek, Martin Zikán, Vít Haluzíková, Denisa Kaválková, Petra Lacinová, Zdeňka Hána, Václav Ďurovcová, Viktória
http://linked.open...ain/vavai/riv/wos	000280363700014
issn	0862-8408
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome

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