About: Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Selective inhibition of neuronal nitric oxide synthase (nNOS) has been shown to prevent brain injury and is important for the treatment of various neurodegenerative disorders. This study shows that not only greater inhibitory potency and isozyme selectivity but more druglike properties can be achieved by fragment hopping. Selective inhibition of neuronal nitric oxide synthase (nNOS) has been shown to prevent brain injury and is important for the treatment of various neurodegenerative disorders. This study shows that not only greater inhibitory potency and isozyme selectivity but more druglike properties can be achieved by fragment hopping. (en)
Title	Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping (en)
skos:prefLabel	Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping (en)
skos:notation	RIV/00064165:_____/09:4002!RIV10-AV0-00064165
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(KAN200200651)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Martásek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	310697
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/09:4002
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amide bond peptidomimetics; favorable binding-sites; ligand probe groups; 2 hydrogen-bonds; de-novo design; escherichia-coli; active-site; dipeptide amides; drug discovery; lead discovery (en)
http://linked.open.../riv/klicoveSlovo	escherichia-coli active-site drug discovery dipeptide amides 2 hydrogen-bonds amide bond peptidomimetics de-novo design favorable binding-sites lead discovery ligand probe groups
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6C6A0AD412FD]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Martásek, Pavel Ji, H. T. Li, HY Poulos, TL Roman, LJ Silverman, RB
http://linked.open...ain/vavai/riv/wos	000263142400021
issn	0022-2623
number of pages	19 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping

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