About: The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To date, only limited information about the influence of ovarian hormones on canine immune system cells has been available. The study investigated the in vitro influence of progesterone and estradiol-17 beta on the activity of canine neutrophils. Treatment of cells by both hormones led to a significant decrease in phagocytosis-induced oxidative burst as detected using luminometry after stimulation with opsonised zymosan. The increase in oxidative burst, not connected with phagocytosis, was recorded after stimulation with a soluble stimulator. Using flow cytometry, the tendency of both hormones to decrease the production of reactive oxygen species associated with phagocytosis of Escherichia coli was also evident, although not significant. Suppression of canine neutrophil activity is not connected with pathogen recognition capabilities, since the expression of Toll-like receptor 4 was unaffected. This study reveals that both hormones have a suppressive effect on the activity of canine neutrophils and thus might contribute to the aetiology of pyometra. To date, only limited information about the influence of ovarian hormones on canine immune system cells has been available. The study investigated the in vitro influence of progesterone and estradiol-17 beta on the activity of canine neutrophils. Treatment of cells by both hormones led to a significant decrease in phagocytosis-induced oxidative burst as detected using luminometry after stimulation with opsonised zymosan. The increase in oxidative burst, not connected with phagocytosis, was recorded after stimulation with a soluble stimulator. Using flow cytometry, the tendency of both hormones to decrease the production of reactive oxygen species associated with phagocytosis of Escherichia coli was also evident, although not significant. Suppression of canine neutrophil activity is not connected with pathogen recognition capabilities, since the expression of Toll-like receptor 4 was unaffected. This study reveals that both hormones have a suppressive effect on the activity of canine neutrophils and thus might contribute to the aetiology of pyometra. (en)
Title	The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils (en)
skos:prefLabel	The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils The effects of in vitro exposure to progesterone and estradiol-17 beta on the activity of canine neutrophils (en)
skos:notation	RIV/00027162:_____/14:#0001092!RIV15-MZE-00027162
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), V, Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Faldyna, Martin Ondráčková, Petra Levá, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	13734
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/14:#0001092
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TLR4; flow cytometry; oxidative burst; phagocytosis; pyometra; dog (en)
http://linked.open.../riv/klicoveSlovo	pyometra flow cytometry TLR4 phagocytosis oxidative burst dog
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0EF7A6DE5CFD]
http://linked.open...i/riv/nazevZdroje	Veterinární medicína
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Levá, Lenka Novotný, R. Ondráčková, Petra Bartošková, A. Vitásek, R. Janošovská, M.
http://linked.open...ain/vavai/riv/wos	000339611100004
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0375-8427
number of pages	8 (xsd:int)

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 89 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software