About: A prototype 'Infucon' device for continuous infusion of microbubbles in vivo

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A device for continuous infusion of microbubbles (MBs) 'Infucon' has been designed, constructed and tested on rabbits. The device prevents MBs from flotation and accumulation in the layer directly below the surface in the syringe injection during i.v. application. Homogenous i.v. application of MBs was tested on 16 male New Zealand White rabbits (average weight about 3.5 kg). Two sorts of MBs were used - a set of commercial SonoVue diagnostic microbubbles (Bracco) and pegylated DPPC microbubbles (PegMBs), which had been prepared in our laboratory. Sulphur hexafluoride was used as a filling gas. The application of MBs by continuous infusion via Infucon prolonged the ultrasound signal period in the heart of the rabbit to 12 min in comparison to about 1 min observed in bolus application. No adverse effects were observed on the tested rabbits after the MB application via Infucon. The principle employed in the prototype device Infucon could be used for development of the device intended for clinical applications. A device for continuous infusion of microbubbles (MBs) 'Infucon' has been designed, constructed and tested on rabbits. The device prevents MBs from flotation and accumulation in the layer directly below the surface in the syringe injection during i.v. application. Homogenous i.v. application of MBs was tested on 16 male New Zealand White rabbits (average weight about 3.5 kg). Two sorts of MBs were used - a set of commercial SonoVue diagnostic microbubbles (Bracco) and pegylated DPPC microbubbles (PegMBs), which had been prepared in our laboratory. Sulphur hexafluoride was used as a filling gas. The application of MBs by continuous infusion via Infucon prolonged the ultrasound signal period in the heart of the rabbit to 12 min in comparison to about 1 min observed in bolus application. No adverse effects were observed on the tested rabbits after the MB application via Infucon. The principle employed in the prototype device Infucon could be used for development of the device intended for clinical applications. (en)
Title	A prototype 'Infucon' device for continuous infusion of microbubbles in vivo A prototype 'Infucon' device for continuous infusion of microbubbles in vivo (en)
skos:prefLabel	A prototype 'Infucon' device for continuous infusion of microbubbles in vivo A prototype 'Infucon' device for continuous infusion of microbubbles in vivo (en)
skos:notation	RIV/00027162:_____/13:#0000975!RIV14-MZE-00027162
http://linked.open...avai/predkladatel	Výzkumný ústav veterinárního lékařství, v.v.i,
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GAP304/10/1951), P(GBP503/12/G147), P(KAN200520703), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Plocková, Jana Turánek, Jaroslav Koudelka, Štěpán Mašek, Josef Kauerová, Zuzana Lukáč, Róbert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	58974
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/13:#0000975
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ultrasonography; Microbubbles; Continuous infusion; Liposome (en)
http://linked.open.../riv/klicoveSlovo	Continuous infusion Microbubbles Ultrasonography Liposome
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CAA8CEA9B68E]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL JOURNAL OF PHARMACEUTICS
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of ultrasound in nanomedicine Centre for studies on toxicity of nanoparticles Nanoliposomes for development of recombinant vaccines and targetted immunotherapeutics St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	441
http://linked.open...iv/tvurceVysledku	Kohout, P. Koudelka, Štěpán Mašek, Josef Turánek, Jaroslav Kauerová, Zuzana Lukáč, Róbert Plocková, Jana Vašíčková, M. Vlašín, P.
http://linked.open...ain/vavai/riv/wos	000314054200011
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0378-5173
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpharm.2012.12.026

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