About: Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall. We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall. (en)
Title	Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis (en)
skos:prefLabel	Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis (en)
skos:notation	RIV/00027162:_____/11:#0000762!RIV12-MZE-00027162
http://linked.open...avai/predkladatel	Výzkumný ústav veterinárního lékařství, v.v.i,
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	56
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Rubeš, Jiří Musilová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	204829
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/11:#0000762
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CELL TRANSPLANTATION; AIRWAY DISEASE; CONDITIONING REGIMEN; TOLERANCE; EPITHELIUM; ALLOGRAFTS; REJECTION; MICRODISSECTION; INDUCTION; INJURY (en)
http://linked.open.../riv/klicoveSlovo	AIRWAY DISEASE ALLOGRAFTS CELL TRANSPLANTATION CONDITIONING REGIMEN EPITHELIUM INDUCTION INJURY MICRODISSECTION TOLERANCE REJECTION
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[34698E8DADE0]
http://linked.open...i/riv/nazevZdroje	Respiratory Research
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Rubeš, Jiří Aittomäki, K. Alho, H. S. Maasilta, P., K. Musilová, Petra Päiväniemi, Outi, E. Raivio, P. M. Salminen, Ulla-Stina
http://linked.open...ain/vavai/riv/wos	000291448500001
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	1465-9921
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis

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