About: Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution

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About: Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The purpose of the present study was to investigate the impact of carcinogenic polycyclic aromatic hydrocarbons and volatile organic compounds on sperm quality in a group of city policemen in Prague. Polymorphisms in metabolic genes folic acid metabolism genes and DNA repair genes were evaluated in these men. The study population was a group of 47 policemen working in the center of the city. No significant differences were found in any of the standard semen parameters between the sampling periods except for vitality of sperms. DNA Fragmentation Index (DFI) were significantly higher in winter than in spring samples for all men and for non-smokers. At the bivariate level, significant associations between hDFI or detDFI and polymorphisms of the repair genes XRCC1, XPD6 and XPD23 were observed. In multivariate models, polymorphisms of the genes XPD6, XPD23 and CYP1A1MspI were associated with high DFI and HDS. Moreover, HDS was significantly associated with polymorphisms in GSTM1 gene. The purpose of the present study was to investigate the impact of carcinogenic polycyclic aromatic hydrocarbons and volatile organic compounds on sperm quality in a group of city policemen in Prague. Polymorphisms in metabolic genes folic acid metabolism genes and DNA repair genes were evaluated in these men. The study population was a group of 47 policemen working in the center of the city. No significant differences were found in any of the standard semen parameters between the sampling periods except for vitality of sperms. DNA Fragmentation Index (DFI) were significantly higher in winter than in spring samples for all men and for non-smokers. At the bivariate level, significant associations between hDFI or detDFI and polymorphisms of the repair genes XRCC1, XPD6 and XPD23 were observed. In multivariate models, polymorphisms of the genes XPD6, XPD23 and CYP1A1MspI were associated with high DFI and HDS. Moreover, HDS was significantly associated with polymorphisms in GSTM1 gene. (en)
Title	Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution (en)
skos:prefLabel	Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution (en)
skos:notation	RIV/00027162:_____/10:#0000628!RIV11-AV0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500390506), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Rubeš, Jiří Rybář, Roman Přinosilová, Petra Věžník, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	260407
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000628
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene-environment interaction; Sperm DNA damage; Sperm chromatin structure assay; Genetic susceptibility; Carcinogenic polycyclic aromatic hydrocarbons; Volatile organic compounds (en)
http://linked.open.../riv/klicoveSlovo	Volatile organic compounds Gene-environment interaction Carcinogenic polycyclic aromatic hydrocarbons Genetic susceptibility Sperm DNA damage Sperm chromatin structure assay
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4057863A8CC5]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Impact of environmental and genetic factors on men fertility
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	683
http://linked.open...iv/tvurceVysledku	Rubeš, Jiří Solanský, I. Přinosilová, Petra Rybář, Roman Věžník, Zdeněk Chvátalová, I. Šrám, R. J.
http://linked.open...ain/vavai/riv/wos	000273845500002
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Animal disease research, prevention and food chain protection
issn	0027-5107
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution

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