About: Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

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About: Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	alpha-Tocopheryl succinate (TOS) exerts selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of TOS for medical application has been reported. We developed and characterised a stable lyophilised liposome-based TOS formulation. TOS (15 mol%) was incorporated into large oligolamellar vesicles composed of soy phosphatidylcholine by the method of lipid film hydration followed by extrusion through polycarbonate filters. Stabilised liposomal formulation was prepared by lyophilisation in the presence of sucrose (molar ratio lipid/sucrose, 1:5). The size distribution of the liposomes (130-140 nm, polydispersity index 0.14) as well as the stable lipid and TOS contents were preserved during storage in the lyophilised form for at least 6 months. The data indicate good physical and chemical stability of the lyophilised preparation of TOS liposomes that can be used in clinical medicine. alpha-Tocopheryl succinate (TOS) exerts selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of TOS for medical application has been reported. We developed and characterised a stable lyophilised liposome-based TOS formulation. TOS (15 mol%) was incorporated into large oligolamellar vesicles composed of soy phosphatidylcholine by the method of lipid film hydration followed by extrusion through polycarbonate filters. Stabilised liposomal formulation was prepared by lyophilisation in the presence of sucrose (molar ratio lipid/sucrose, 1:5). The size distribution of the liposomes (130-140 nm, polydispersity index 0.14) as well as the stable lipid and TOS contents were preserved during storage in the lyophilised form for at least 6 months. The data indicate good physical and chemical stability of the lyophilised preparation of TOS liposomes that can be used in clinical medicine. (en)
Title	Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation (en)
skos:prefLabel	Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation (en)
skos:notation	RIV/00027162:_____/10:#0000617!RIV11-AV0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KAN200520703), Z(AV0Z50520701), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Turánek, Jaroslav Koudelka, Štěpán Mašek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	269062
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000617
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alpha-tocopheryl succinate; apoptosis; cancer; extrusion; liposome; lyophilisation; nanotechnology; particle size; stability; vitamin E analogues (en)
http://linked.open.../riv/klicoveSlovo	particle size cancer nanotechnology stability extrusion apoptosis liposome alpha-tocopheryl succinate lyophilisation vitamin E analogues
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6CEFC2FE6893]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of ultrasound in nanomedicine
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Koudelka, Štěpán Mašek, Josef Turánek, Jaroslav Neužil, J.
http://linked.open...ain/vavai/riv/wos	000277132500020
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR Animal disease research, prevention and food chain protection
issn	0022-3549
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

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