About: Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Paclitaxel (PTX) is approved for the treatment of ovarian and breast cancer. The commercially preparation of PTX is associated with hypersensitivity reactions. The developed liposomal PTX formulations are troubled with low PTX encapsulation capacity (maximal content, 3 mol%) and accompanied by PTX crystallisation. Stable lyophilised preparation of PTX (7 mol%) encapsulated in the liposomes composed of SOPC/POPG/MOPC lipids (molar ratio, 60:20:20) doped with 5 mol% vitamin E had the size of 180-190 nm with zeta-potential of -31 mV. Sucrose (lipid/sugar molar ratio, 1:5-10) was found to preserve physical stability of PTX liposomes. This liposomal formulation did not show any evidence of toxicity in C57BL/6 mice treated with the highest doses of PTX (100 mg/kg as a single dose and 150 mg/kg as a cumulative dose applied in 3 equivalent doses in 48-h intervals). A dose-dependent anticancer effect was found in both hollow fibre implants and syngenic B16F10 melanoma mouse tumour models. Paclitaxel (PTX) is approved for the treatment of ovarian and breast cancer. The commercially preparation of PTX is associated with hypersensitivity reactions. The developed liposomal PTX formulations are troubled with low PTX encapsulation capacity (maximal content, 3 mol%) and accompanied by PTX crystallisation. Stable lyophilised preparation of PTX (7 mol%) encapsulated in the liposomes composed of SOPC/POPG/MOPC lipids (molar ratio, 60:20:20) doped with 5 mol% vitamin E had the size of 180-190 nm with zeta-potential of -31 mV. Sucrose (lipid/sugar molar ratio, 1:5-10) was found to preserve physical stability of PTX liposomes. This liposomal formulation did not show any evidence of toxicity in C57BL/6 mice treated with the highest doses of PTX (100 mg/kg as a single dose and 150 mg/kg as a cumulative dose applied in 3 equivalent doses in 48-h intervals). A dose-dependent anticancer effect was found in both hollow fibre implants and syngenic B16F10 melanoma mouse tumour models. (en)
Title	Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect (en)
skos:prefLabel	Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect (en)
skos:notation	RIV/00027162:_____/10:#0000612!RIV11-MZE-00027162
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Plocková, Jana Korvasová, Zina Turánek, Jaroslav Koudelka, Štěpán Mašek, Josef Bartheldyová, Eliška Turánek-Knötigová, Pavlína Škrabalová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	268613
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000612
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	B16F10; extrusion; hollow fibre implants; liposomes; lyophilisation; melanoma; nanotechnology; paclitaxel; particle size; stability (en)
http://linked.open.../riv/klicoveSlovo	particle size nanotechnology stability extrusion liposomes melanoma paclitaxel lyophilisation B16F10 hollow fibre implants
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[836C411E3817]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Bartheldyová, Eliška Koudelka, Štěpán Mašek, Josef Turánek, Jaroslav Škrabalová, Michaela Korvasová, Zina Plocková, Jana Turánek-Knötigová, Pavlína
http://linked.open...ain/vavai/riv/wos	000277132500009
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0022-3549
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect Liposomes With High Encapsulation Capacity for Paclitaxel: Preparation, Characterisation and In Vivo Anticancer Effect

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