About: Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	If any new live Salmonella vaccine is introduced in the future, it is quite probable that detailed characterisation of attenuation will be required. In this study we compared 34 isogenic mutants of S. Enteritidis in aroA, aroD, galE, ssrA, sseA, phoP, rpoS, ompR, htrA, clpP, lon, rfaL, rfaG, rfaC, hfq, sodCI, hilA, sipA, avrA, sopB, sopA, sopE, sifA, shdA, fliC, fur, relA, spoT, relA-spoT, misL, rmbA, STM4258, STM4259 and spvBC genes for their resistance to stresses and for their virulence and immunogenicity in Balb/C mice. We found that the cold and bile resistances did not correlate with the resistances to other stresses. Resistance to acid pH, heat, polymyxin and serum correlated with each other and also with the attenuation. When the residual virulence and immunogenicity were both considered, mutants in htrA, ompR, aroA, aroD and lon performed the best in mice. Furthermore, when a comparison of polymyxin and serum sensitive mutants was performed, the serum sensitive mutants were more immunogenic. If any new live Salmonella vaccine is introduced in the future, it is quite probable that detailed characterisation of attenuation will be required. In this study we compared 34 isogenic mutants of S. Enteritidis in aroA, aroD, galE, ssrA, sseA, phoP, rpoS, ompR, htrA, clpP, lon, rfaL, rfaG, rfaC, hfq, sodCI, hilA, sipA, avrA, sopB, sopA, sopE, sifA, shdA, fliC, fur, relA, spoT, relA-spoT, misL, rmbA, STM4258, STM4259 and spvBC genes for their resistance to stresses and for their virulence and immunogenicity in Balb/C mice. We found that the cold and bile resistances did not correlate with the resistances to other stresses. Resistance to acid pH, heat, polymyxin and serum correlated with each other and also with the attenuation. When the residual virulence and immunogenicity were both considered, mutants in htrA, ompR, aroA, aroD and lon performed the best in mice. Furthermore, when a comparison of polymyxin and serum sensitive mutants was performed, the serum sensitive mutants were more immunogenic. (en)
Title	Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential (en)
skos:prefLabel	Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential (en)
skos:notation	RIV/00027162:_____/09:#0000531!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(QH91238), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	38
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šebková, Alena Havlíčková, Hana Rychlík, Ivan Šišák, František Karasová, Daniela Vrbas, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	307637
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000531
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Salmonella; Enteritidis; vaccine (en)
http://linked.open.../riv/klicoveSlovo	Salmonella Enteritidis vaccine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D6079BF50BD2]
http://linked.open...i/riv/nazevZdroje	Vaccine
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Vaccination and protection of poultry against Salmonella infection
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Havlíčková, Hana Karasová, Daniela Rychlík, Ivan Šišák, František Šebková, Alena Vrbas, Vladimír
http://linked.open...ain/vavai/riv/wos	000269071900018
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0264-410X
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 41 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software